炎症因子与子宫腺肌病发病机制研究进展  

Advances in Research on the Pathogenesis of Inflammatory Factors and Adenomyosis

作　　者：孙瑶琦 蒋惠慈 刘洁(审校)[1] SUN Yao-qi;JIANG Hui-ci;LIU Jie(Department of Obstetrics and Gynecology,Tenth People′s Hospital of Tongji University,Shanghai 200072,China;Shanghai Tenth Hospital,School of Clinical Medicine of Nanjing Medical University,Shanghai 200072,China)

机构地区：[1]同济大学附属第十人民医院妇产科,上海200072 [2]南京医科大学上海十院临床医学院

出　　处：《国际妇产科学杂志》2020年第1期96-100,共5页Journal of International Obstetrics and Gynecology

摘　　要：子宫腺肌病是一种具有增殖、浸润及转移能力的良性妇科疾病,多见于40~50岁的女性,常引起月经过多、进行性痛经及不孕等症状,极大地影响着女性的身心健康。但由于其具体的发病机制尚未阐明,对于该病有效地预防及治疗一直是困扰妇科医生的难题。近年研究发现该病患者体内的免疫细胞及免疫因子的异常表达可能与子宫腺肌病的发生发展密切相关,如白细胞介素1β(interleukin-1β,IL-1β)的异常升高可诱导子宫内膜炎症反应的启动,IL-6的表达增加使子宫内膜的增殖与侵袭能力增强,IL-10表达的异常导致子宫腺肌病患者正常免疫抑制功能的失调,IL-18、IL-8和肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)亦与子宫内膜的炎症反应有关,因此子宫腺肌病逐渐被认为是一种慢性炎性疾病。故本文就近年炎症因子在子宫腺肌病发病机制中的作用研究进展进行综述,旨在为子宫腺肌病的诊治提供新的思路。Adenomyosis is a benign gynecological disease with proliferative, invasive and metastatic ability. It is more common in women aged 40-50 years old. It often causes menorrhagia, progressive dysmenorrhea and infertility, which greatly affects women′s physical and mental health. Domestic and foreign literature reports that the pathogenesis of adenomyosis may be related to estrogen, tissue injury and repair mechanisms, genetics and immunity. However, because its specific pathogenesis has not yet been elucidated, effective prevention and treatment of the disease has always been a difficult problem for gynecologists. In recent years, it has been found that the abnormal expression of immune cells and immune factors in patients with this disease may be closely related to the onset and progression of adenomyosis. For example, abnormal elevation of interleukin-1β(IL-1β) induces the activation of endometrial inflammation, increased expression of IL-6 enhances the proliferation and invasion of the endometrium, abnormal expression of IL-10 leads to dysregulation of normal immunosuppressive function in patients with adenomyosis. IL-18, IL-8 and TNF-α are also involved in the inflammatory response of the endometrium, and thus adenomyosis is gradually considered to be a chronic inflammatory disease. Therefore, this paper reviews the research progress of the role of inflammatory factors in the pathogenesis of adenomyosis in recent years, aiming to provide new ideas for the diagnosis and treatment of adenomyosis.

关 键 词：子宫腺肌病 免疫因子类 白细胞介素类 肿瘤坏死因子Α 

分 类 号：R711.71[医药卫生—妇产科学]