生长分化因子9对卵巢功能的影响和调控  

Effect and Regulation of Growth Differentiation Factor 9 on Ovarian Function

作　　者：张印峰[1] 王会妍[1] 张云山[1] ZHANG Yin-feng;WANGHui-yan;ZHANG Yun-shan(Reproductive Medicine Center,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院生殖医学中心

出　　处：《国际生殖健康／计划生育杂志》2020年第1期54-58,共5页Journal of International Reproductive Health/Family Planning

摘　　要：生长分化因子9(growth differentiation factor 9,GDF-9)是转化生长因子β(transforming growth factor beta,TGF-β)超家族的新成员。作为卵母细胞分泌的因子,GDF-9在女性生殖功能中的作用近年得到广泛讨论。研究发现GDF-9可参与调节颗粒细胞分化发育,相关功能蛋白、因子产生,生殖系统相关基因表达以及卵巢细胞代谢、凋亡等过程,从而在卵巢卵泡生长及卵母细胞成熟、排卵和黄素化等方面发挥重要作用。骨形态发生蛋白15(BMP-15)是一种与GDF-9具有高度氨基酸同源性和相似蛋白结构的卵母细胞源性因子,研究发现GDF-9可与BMP-15形成异源二聚体并发挥协同作用。目前认为,GDF-9是卵母细胞与颗粒细胞完成双向通讯重要的影响因子,参与两种细胞的同步化通讯和协调生长过程,其异常表达可能与女性生殖内分泌失调及随之引发的不孕存在一定关系。本文从GDF-9对卵母细胞发育的影响及在卵泡形成过程中的调控等方面,对其影响和调节卵巢功能的作用进行综述。Growth differentiation factor 9(GDF-9) is a new member of transforming growth factor beta(TGF-β) superfamily. The role of GDF-9 as a factor secreted by oocyte has been broadly discussed in recent years. GDF-9 participates in regulating the differentiation and development of granulosa cells, the production of relative proteins and factors, the expression of genes related to the reproductive system, and the metabolism and apoptosis of ovarian cells. GDF-9 is therefore a vital factor of folliculogenesis, maturation of oocytes, ovulation and luteinization. Furthermore, BMP-15 is another oocyte-derived factor which shares high-homologous amino acid sequences and similar protein structure with GDF-9. GDF-9 and BMP-15 can form a heterodimer, in which they have synergistic effects. Now it′ s believed that GDF-9 is an impotant factor of the two-way communication between oocyte and granulosa cells, and that GDF-9 participates in the synchronous communication and coordinated growth of the two kinds of cells. The abnormal expression of GDF-9 may be associated with female reproductive endocrine disorders and subsequent infertility. Here we reviewed the effects of GDF-9 on ovarian function, including the regulation of oocyte development and folliculogenesis.

关 键 词：生长分化因子9 颗粒细胞 卵丘细胞 卵母细胞 卵巢 

分 类 号：R714.8[医药卫生—妇产科学]