中风多虚多瘀多痰病机与自噬调控相关性的研究进展  

Advances in Study of the Relationship Between the Pathogenesis of Multiple Deficiency,Multiple Stagnant Phlegm and Autophagy Regulation

作　　者：黄显雯 刘启华[1] 邹玲 李南方 陈永斌[1] HUANG Xian-wen;LIU Qi-hua;ZOU Ling;LI Nan-fang;CHEN Yong-bin(ThE-First Affiliated Hospital of Guangxi Medical University,Nanning,530021,China;ThE-First Clinical Medical College,Guangxi Medical University,Nanning,530021,China)

机构地区：[1]广西医科大学第一附属医院,广西南宁530021 [2]广西医科大学第一临床医学院,广西南宁530021

出　　处：《南京中医药大学学报》2020年第1期130-135,共6页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81560790);广西自然科学基金(2014GxNSFAA118277)

摘　　要：诸多研究发现中医治疗中风的分子作用机制中,细胞自噬可减轻脑损伤、保护神经、保护血管内皮细胞及促进血管新生,其"双向调节"与中医维持"阴阳平衡"协调状态相契合,因此探讨中风病机与自噬的相关性显得有趣而重要。基于细胞自噬理论,将自噬通过多条通路应对胞质内钙超载、内质网应激、谷氨酸盐中毒、自噬反应与"气虚""血瘀""痰浊"中风病机相结合,分析2者的相似性及关联性,并提出细胞自噬可能通过多条通路发挥的"双向调节"在中风的发生、发展与转归中起重要作用,为进一步探索自噬在中风中的作用机制提供新思路。Many studies have found that in the molecular mechanism of action of traditional Chinese medicine for treating stroke,autophagy can reduce brain damage,protect nerves,protect vascular endothelial cells and promote angiogenesis.Its"two-way regulation" is consistent with the maintenance of" yin-yang balance" coordination state by Chinese medicine.Therefore,it is interesting and important to explore the correlation between the pathogenesis of traditional Chinese medicine and autophagy.Based on the theory of autophagy,autophagy responds to intracytoplasmic calcium overload,endoplasmic reticulum stress,glutamate poisoning,autophagy,and"qi deficiency" "blood stasis" and"turbidity" stroke through multiple pathways.The combination of pathogenesis and pathogenesis analyzes the similarity and correlation between the two,and proposes that the "two-way regulation" of autophagy through multiple pathways plays an important role in the occurrence,development and outcome of stroke,for further exploration.The mechanism of action in stroke is a new idea.

关 键 词：中风 自噬 双向调节 气虚 血瘀 痰浊 

分 类 号：R255.2[医药卫生—中医内科学]