中医心理低阻抗意念导入疗法(TIP技术)治疗抑郁症的临床疗效研究:一项多中心、随机对照试验  

Low Resistance State Thought Induction Psychotherapy( TIP) for Depression:a Multicenter Randomized Controlled Study

作　　者：吕学玉[1] 冯帆[1] 丰云舒 李艳[2] 杨冬蓉 都弘[3] 陈建荣 王国强[4] 陈新宇[4] 王健[1] 洪兰[1] 张锦花[1] 李桂侠[1] 杜辉[1] 王处渊 汪卫东[1] Lyu Xueyu;Feng Fan;Feng Yunshu;Li Yan;Yang Dongrong;Du Hong;Chen Jianrong;Wang Guoqiang;Chen Xinyu;Wang Jian;Hong Lan;Zhang Jinhua;Li Guixia;Du Hui;Wang Chuyuan;Wang Weidong(Guang′an Men Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;TCM Hospital of Guangdong Province,Guangzhou 510000,China;Shenyang Mental Health Center,Shenyang 110168,China;Wuxi Mental Health Center,Wuxi 214000,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]广东省中医院,广州519015 [3]沈阳市精神卫生中心,沈阳110168 [4]无锡市精神卫生中心,无锡214000

出　　处：《世界中医药》2019年第12期3410-3413,共4页World Chinese Medicine

基　　金：“十二五”国家科技支撑计划(2014BAI10B07)——病证结合治疗抑郁症的临床评价研究;国家自然科学基金项目(81603673)——中医松静功纠正抑郁症过度自我觉知对相关脑网络的影响

摘　　要：目的:比较中医心理TIP技术与西方CBT技术干预抑郁症疗效,观察长期疗效;方法:采用多中心随机对照试验,选取2015年1月至2017年9月的抑郁症患者225例作为研究对象,随机分为A、B、C 3组,分别接受TIP、CBT、电针+中药+TIP治疗,干预12周,随访1年。评估工具为汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、贝克抑郁量表(BDI),在治疗前、治疗4、8、12周及随访1年时测评,每组脱落10例,共有195例患者完成试验。结果:随着治疗周期的增长,3组治疗有效率均在稳步提升。并且在第12周达到最高有效率。相对来看,综合疗法的治疗有效率最高为80.8%,而TIP疗法,CBT疗法在第12周的治疗有效率分别是72.9%和72.3%,但三者差异无统计学意义(χ^2=4.941,P=0.051);随访1年时,C组复发率最高,32.5%,显著高于A组(15%),B组(10.3%),差异有统计学意义(χ^2=6.774,P=0.034);结论:该部分研究显示A组与C组疗效相当,长期疗效优于C组。Objective:To compare the clinical efficacy of the TIP and CBT,and to observe the long-term effect.Methods:Multicenter randomized controlled trial was designed.225 patients with depression from January 2015 to September 2017 were enrolled and randomized into 3 groups,who received TIP,CBT and electroacupuncture+Chinese herbal medicine+TIP treatment respectively.The intervention period was 12 weeks and follow-up in 1 year.The assessment tools were the Hamilton Depression Scale(HAMD),the Hamilton Anxiety Scale(HAMA),and the Baker Depression Scale(BDI).They were measured before treatment,at 4,8,12 weeks of treatment,and at 1 year of follow-up.10 cases dropped in each group.A total of 195 patients completed the trial.Results:With the increase of the treatment cycle,the treatment efficiency of the 3 groups was steadily improved,and reached the highest in the 12th week.In contrast,the maximum effective rate of comprehensive therapy was 80.8%,while the effective rates of TIP therapy and CBT therapy at week 12 were 72.9%and 72.3%,respectively,but the difference between the 3 groups was not statistically significant(χ^2=4.941,P=0.051);at 1 year of follow-up,the recurrence rate was 32.5%,the highest in the CBT group,which was significantly higher than that in the TIP group(15%)and the comprehensive group(10.3%),and the difference was statistically significant(χ^2=6.774,P=0.034).Conclusion:This part of the study shows that the TIP group is equivalent to the CBT group,and the long-term effect is better than the CBT group.

关 键 词：低阻抗意念导入疗法 认知行为疗法 抑郁症 多中心 随机对照 

分 类 号：R277.7[医药卫生—中医学]