可双光子激发的聚集诱导发光光敏剂及其生物医学应用  

Two-photon Excitable Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

作　　者：武文博 刘斌[1] WU Wenbo;LIU Bin(Department of Chemical and Biomolecular Engineering,National University of Singapore,Singapore 117585,Republic of Singapore)

机构地区：[1]新加坡国立大学化学工程与分子生物工程系

出　　处：《高等学校化学学报》2020年第2期191-203,共13页Chemical Journal of Chinese Universities

基　　金：Singapore National Research Foundation Competitive Research Program(No.R279-000-483-281);National Research Foundation Investigatorship(No.R279-000-444-281);the National University of Singapore(No.R279-000-482-133)资助

摘　　要：综合评述了双光子激发的聚集诱导发光(AIE)光敏剂的研究进展,重点讨论了双光子激发的AIE光敏剂的设计思路及在生物医学中的应用,并对其发展前景进行了展望。The concept of two-photon excited photodynamic therapy based on photosensitizers with aggregation-induced emission( AIE) takes advantages of high penetration depth and precision from two-photon technology,and high photosensitization efficiency in aggregate state from AIE photosensitizers. In this contribution,we review the recent progress in this field,which includes the design principles of two-photon excitable AIE photosensitizers,specific examples of AIE photosensitizers and their biomedical applications.The perspectives for the future development of this field was also discussed.

关 键 词：聚集诱导发光 光敏剂 光动力治疗 双光子激发 

分 类 号：O621.2[理学—有机化学] O69[理学—化学]