双亲性石墨烯量子点的合成及对L-薄荷醇的缓释作用  

Synthesis of Amphiphilic Graphene Quantum Dots and Their Sustained Release Effect on L-Menthol

作　　者：李明 崔小倩 汪璇 李在均 LI Ming;CUI Xiaoqian;WANG Xuan;LI Zaijun(Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学化学与材料工程学院合成与生物胶体教育部重点实验室

出　　处：《高等学校化学学报》2020年第2期324-330,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21576115)资助~~

摘　　要：将柠檬酸和直链烷基胺混合后热解,制备了烷基胺功能化的双亲性石墨烯量子点。研究结果表明,烷基碳链长度对石墨烯量子点的表面活性有较大影响。采用十二烷基胺为功能试剂时,石墨烯量子点的表面张力降低到30. 8 mN/m,与典型的阴离子表面活性剂十二烷基苯磺酸钠相当。此双亲性石墨烯量子点被用作固体粒子表面活性剂稳定L-薄荷醇/水Pickering乳液时,所形成的乳液具有较高的稳定性,液滴平均粒径为10μm。该乳液冷却至室温后析出结晶,将晶体过滤、干燥后得到负载L-薄荷醇的石墨烯量子点。采用热风吹扫方式研究石墨烯量子点对L-薄荷醇的缓释行为。在80℃下,负载型样品完全释放薄荷醇所需要的时间分别为混合型样品和空白样品的4. 6倍与9. 2倍,表明石墨烯量子点对L-薄荷醇具有明显的缓释作用。Amphiphilic alkyl amine functionalized graphene quantum dots( AA-GQD) were synthesized by one-step thermal decomposition with citric acid and linear alkyl amine as raw materials. The results showed that the alkyl carbon chain length had a great effect on the surface activity of AA-GQD. When the dodecylamine was used as the functional reagent,the surface tension of the dodecylamine functionalized graphene quantum dots( DA-GQD) was reduced to 30. 8 mN/m,which was close to that of the typical anionic surfactant sodium dodecyl benzene sulfonate. DA-GQD was then used as a solid particle emulsifier to stabilize L-menthol in water Pickering emulsion. The formed emulsion had high stability with the average particle size of emulsion being about 10 μm. After the emulsion was cooled to room temperature,crystals were precipitated. The precipitate was filtered and dried to obtain the DA-GQD loaded with L-menthol. The effect of DA-GQD on the release behavior of menthol was studied by means of hot air sweeping. It was found that the time required for the complete release of menthol in the 1. 0%DA-GQD loaded sample was 4. 6 times and 9. 2 times that of menthol in the mixed sample and the blank sample,respectively. The above results show that DA-GQD has a significant sustained release effect on L-menthol. GQDs contain rich functional groups such as hydroxyl group and carboxy group that might interact strongly with L-menthol,resulting in improved release behavior of the loaded sample.

关 键 词：双亲性石墨烯量子点 L-薄荷醇 Pickering乳液 缓释 

分 类 号：O647[理学—物理化学]