猪肺磷脂注射液治疗新生儿胎粪吸入性肺炎临床评价  

Poractant Alfa Injection in Treating Neonates with Meconium Aspiration Pneumonia

作　　者：任娜芳 黄秀群 谭静 冯小燕 欧阳红 刘晓 刘湘 REN Nafang;HUANG Xiuqun;TAN Jing;FENG Xiaoyan;OUYANG Hong;LIU Xiao;LIU Xiang(Department of Neonatology,Xiang tan Central Hospital,Xiangtan,Hunan,China 411100)

机构地区：[1]湖南省湘潭市中心医院新生儿科

出　　处：《中国药业》2020年第4期92-95,共4页China Pharmaceuticals

基　　金：湖南省卫生计生委科研计划课题项目[B2017167]

摘　　要：目的探讨猪肺磷脂注射液治疗新生儿胎粪吸入性肺炎的临床疗效及对患儿肺氧合功能、炎性因子、预后的影响。方法选取医院2015年1月至2018年1月收治的胎粪吸入性肺炎新生儿患儿86例,按随机数字表法分为对照组及观察组,各43例。两组患儿均采用常规综合治疗,观察组患儿加用猪肺磷脂注射液(150 mg/kg),均连续治疗7 d。结果观察组总有效率为95.35%,明显高于对照组的74.42%(P<0.05);治疗后,两组患儿的动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)均有不同程度改善,且观察组均明显优于对照组(P<0.05);两组患儿血清肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)水平均明显降低(P<0.05),且观察组降幅明显大于对照组(P<0.05);观察组患儿的住院时间、氧疗时间、肺部湿罗音消失时间、发绀消失时间、呼吸困难缓解时间及血氧饱和度(SpO2)恢复正常时间均明显短于对照组(P<0.05),吸痰次数明显少于对照组(P<0.05);观察组与对照组不良反应发生率相当(20.93%比18.60%,P>0.05)。结论猪肺磷脂注射液治疗新生儿胎粪吸入性肺炎,能明显抑制炎性反应,改善肺氧合功能及预后。Objective To discuss the clinical efficacy and impact of pulmonary oxygenation function,inflammatory factor,prognosis on neonates with meconium aspiration pneumonia treated by Poractant Alfa Injection.Methods A total of 86 cases of neonate patients with meconium aspiration pneumonia from January 2015 to January 2018 in the hospital were selected and divided into the control group and the observation group according to the random number table method,43 cases in each group.Both groups were given conventional comprehensive treatment,and the observation group was added with Poractant Alfa Injection(150 mg/kg).All patients were continually treated for 7 d.Results The total effective rate of the observation group was 95.35%,which was significantly higher than74.42%in the control group(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2)and PaO2/FiO2 was improved inordinately in the two groups,and the PaO2 and PaO2/FiO2 of the observation group was significantly higher than those of the control group at every time point(P<0.05).The serum level of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)was obviously decreased in the two groups,and the descent degrees of the observation group were significantly higher than those of control group(P<0.05).The hospital stays,oxygen therapy time,SPO2 recovery time,pulmonary moist rale disappeared time,cyanosis disappeared time,dyspnea remission time of observation group were significantly shorter than those of the control group(P<0.05)and the sputum aspirator times were significantly less than those of the control group(P<0.05).There was no statistical significance on the adverse reaction rate between the two groups(20.93%vs.18.60%,P>0.05).Conclusion Poractant Alfa Injection in the treatment of neonates with meconium aspiration pneumonia could obviously inhibit inflammatory reaction,improve pulmonary oxygenation function and prognosis.

关 键 词：胎粪吸入性肺炎 新生儿 猪肺磷脂注射液 临床疗效 炎性因子 肺氧合功能 预后 

分 类 号：R969.4[医药卫生—药理学] R985[医药卫生—药学]