鹿瓜多肽联合唑来膦酸治疗骨质疏松性骨折椎体成形术后的疗效及对炎性因子的影响  

Lugua Polypeptide Combined with Zoledronic Acid in the Treatment of Patients with Osteoporotic Fractures After Vertebroplasty and Its effect on Inflammatory Factors

作　　者：夏庆泉 吴旭华 容可 周振宇[1] 殷潇凡 安智全[2] XIA Qingquan;WU Xuhua;RONG Ke;ZHOU Zhenyu;YIN Xiaofan;AN Zhiquan(Department of Orthopaedics,Minhang Hospital Affiliated to Fudan University,Shanghai,China 201100;Department of Orthopaedics,Sixth People′s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai,China 200233)

机构地区：[1]复旦大学附属闵行医院骨科,上海201100 [2]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国药业》2020年第3期84-86,共3页China Pharmaceuticals

基　　金：2016年度上海市卫生和计划生育委员会科研课题[20164054]

摘　　要：目的探讨鹿瓜多肽联合唑来膦酸治疗骨质疏松性骨折患者椎体成形术后的疗效及对炎性因子的影响。方法选取上海复旦大学附属闵行医院2016年6月至2018年2月收治的骨质疏松性骨折患者120例,根据随机数字表法分为对照组和研究组,各60例。对照组患者给予唑来膦酸治疗,研究组患者在对照组基础上加用鹿瓜多肽治疗。结果治疗6个月后,研究组的临床总有效率为76. 67%,高于对照组患者的58. 33%(P <0. 05)。治疗8周后,两组患者红细胞积聚指数(EAI)、红细胞电泳指数(EEI)均降低,且研究组低于对照组(P <0. 05);红细胞免疫促进因子(FEER)、直向肿瘤红细胞花环率(DTER)均升高,且研究组高于对照组(P <0. 05)。治疗8周后,两组患者白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均降低,且研究组低于对照组(P <0. 05)。两组患者不良反应发生率相当(16. 67%比13. 33%,P> 0. 05)。结论骨质疏松性骨折椎体成形术后应用鹿瓜多肽联合唑来膦酸治疗,疗效显著,可改善患者愈合情况,降低炎性因子水平,且不增加不良反应发生率。Objective To investigate the efficacy of Lugua polypeptide combined with zoledronic acid for osteoporotic fracture after vertebroplasty and its effect on inflammatory factors. Methods A total of 120 patients with osteoporotic fracture who received in Minhang Hospital Affiliated to Fudan University from June 2016 to February 2018 were selected and divided into the control group and the study group according to the random number table method,60 cases in each group. The control group was treated with zoledronic acid,and the study group was treated with Lugua polypeptide on the basis of the control group. Results After 6 months of treatment,the total effective rate of the study group was 76. 67%,which was higher than 58. 33% of the control group( P < 0. 05). After 8 weeks of treatment,the erythrocyte aggregation index( EAI) and erythrocyte electrophoresis index( EEI) decreased in the two groups,and the values in the study group were lower than those in the control group( P < 0. 05);the erythrocyte immune stimulating factor( FEER) and erythrocyte rosette rate( DTER) increased in the two groups,and the values in the study group were higher than those in the control group( P < 0. 05). After 8 weeks of treatment,the interleukin-6( IL-6),tumor necrosis factor-α( TNF-α) and C-reactive protein( CRP) were all decreased in both groups,and the levels in the study group were lower than those in the control group( P < 0. 05).There was no significant difference in the incidence of adverse reactions between the two groups( 16. 67% vs. 13. 33%,P > 0. 05).Conclusion Lugua polypeptide combined with zoledronic acid is quite effective in the treatment of osteoporotic fracture after vertebroplasty.It can improve the healing of patients,reduce the level of inflammatory factors,and do not increase the incidence of adverse reactions.

关 键 词：鹿瓜多肽 唑来膦酸 骨质疏松性骨折 椎体成形术 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R683.2[医药卫生—药学]