中医药在调节胃肠道菌群以防治胃肠道肿瘤中的作用和意义  

Role and significance of traditional Chinese medicine in regulating gastrointestinal microecology to prevent and treat gastrointestinal cancer

作　　者：朱广辉 桑毅婷 李杰[1] Guang-Hui Zhu;Yi-Ting Sang;Jie Li(Department of Oncology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院肿瘤科

出　　处：《世界华人消化杂志》2020年第1期1-8,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目,Nos.81473463,81774289;北京市科技计划项目,No.D161100005116004~~

摘　　要：近年的研究显示:胃肠道微生态与胃肠道恶性肿瘤的发生发展及抗肿瘤治疗密切相关.有效调节胃肠道微生态对防治胃肠道肿瘤具有重要作用.中医药多采用口服进药方式,可以直接发挥调节胃肠道微生态作用,通过改善胃肠道微生态结构、保护胃肠道黏膜屏障、防止菌群移位、增强胃肠黏膜免疫功能等多途径对胃肠道恶性肿瘤起到干预作用,其中在改善癌前状态及联合抗肿瘤治疗提高临床疗效等方面可以发挥重要作用.现代研究显示:胃肠道微生态与脾虚证、湿热证关系密切,中医药可以健脾和胃、清热祛湿为治则,遵循“病证结合”的诊疗思维,通过调节肠道微生态新视角防治胃肠道肿瘤具有重要意义,希冀为中医药抗肿瘤研究提供新策略.Recent studies have shown that gastrointestinal microecology is closely related to the occurrence and development of gastrointestinal cancers and antitumor treatment efficacy,so effective regulation of gastrointestinal microecology plays an important role in the prevention and treatment of gastrointestinal cancers.Traditional Chinese medicine,adopting oral administration,can directly regulate gastrointestinal microecology.Traditional Chinese medicine can improve the precancerous condition and enhance the clinical efficacy of anti-tumor treatment via multiple mechanisms,such as improving the microecological structure of the gastrointestinal tract,protecting the gastrointestinal mucosal barrier,preventing the translocation of the flora,and enhancing the immune function of the gastrointestinal mucosa.Some research has shown that the imbalance of gastrointestinal microecology is closely related to spleen deficiency syndrome and damp-heat syndrome.The therapeutic principles of traditional Chinese medicine can be Jianpi Hewei and Qingre Qushi following the concept of“combination of disease and syndrome”.It is of great significance to prevent and cure gastrointestinal tumors from a new perspective of regulating intestinal microecology.We hope of providing new strategies for the anti-tumor research of traditional Chinese medicine.

关 键 词：胃肠道肿瘤 胃肠道微生态 中医药治疗 多途径 临床定位 病证结合 

分 类 号：R259[医药卫生—中西医结合]