低剂量阿司匹林对内异症患者冻胚移植的影响  

Effect of low-dose aspirin on frozen embryo transfer in endometriosis

作　　者：杜彦博 崔文娟 孙梅 Du Yan-bo;Cui Wen-juan;Sun Mei(Reproductive Hospital Affiliated to Shandong University,Shandong Jinan 250000,China)

机构地区：[1]山东大学附属生殖医院

出　　处：《实用妇科内分泌电子杂志》2019年第26期1-3,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨小剂量阿司匹林在子宫内膜异位症(EM)患者人工周期冻胚移植(FET)妊娠结局的影响。方法收集2013年1月至2017年6月期间在我生殖中心行FET治疗的EM患者218例为研究对象。根据患者FET期间有无使用阿司匹林分组。回顾性分析阿司匹林组(n=87)与对照组(n=131)之间的临床妊娠率、早期流产率、早产率、活产率等指标。结果阿司匹林组患者的妊娠率(64.4%vs 61.4%,P=0.671)略高于对照组,但无统计学意义。且对照组及阿司匹林组在胚胎种植率、早期流产率、中晚期流产率、活产率、等方面均无显著差异。结论小剂量阿司匹林的应用对EM患者人工周期FET的获益不大。Objective To investigate the effect of low dose aspirin on the outcome of frozen embryo transfer(FET)cycles in the patients with endometriosis(EM).Methods 280 EM patients undergone FET cycles in the Reproductive Hospital affiliated Shandong University from January 2013 to June 2017 were recruited.The patients were divided into two groups according to whether or not using aspirin.The rate of clinical pregnancy,early abortion rate,late abortion rate,incidence of ectopic gestation,the rate of premature birth and live birth rate were compared between the aspirin group(n=87)and control group(n=131).Results The rate of clinical pregnancy in aspirin group was slightly increased compared with control group(64.4%vs 61.4%,P=0.4671),but the difference was no statistical significance.And there was no significantly difference in the rate of embryo implantation,early abortion rate,late abortion rate,and live birth rate between the two groups.Conclusion The application of low-dose aspirin has little benefit to the artificial cycle FET of EM patients.

关 键 词：子宫内膜异位症 冻融胚胎移植 阿司匹林 人工周期 

分 类 号：R711.71[医药卫生—妇产科学]