血液净化治疗神经系统免疫性疾病时机与模式选择  

Choices of timing and mode of blood purification in the treatment of immune diseases of nervous system

作　　者：丁敏 张圳[1] 李玉梅[1] DING Min;ZHANG Zhen;LI Yu-mei(Department of Pediatric Intensive Care Unit,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院儿童重症医学科

出　　处：《中国实用儿科杂志》2019年第12期993-997,共5页Chinese Journal of Practical Pediatrics

摘　　要：神经系统免疫性疾病是由免疫机制介导的一类神经系统疾病,高致死率及高致残率是其重要的特点,早期干预治疗会明显改善患儿的临床结局。目前治疗该类疾病的主要方式包括应用皮质类固醇激素、静脉注射丙种球蛋白(IVIG)和血液净化治疗,而血液净化治疗因其具有起效快等优势成为目前研究关注的热点,其主要治疗模式为血浆置换及血浆免疫吸附,对于急性发作、病情危重的患儿血液净化越早应用可能会带来越显著的临床改善。血液净化对于危重症或者其他药物治疗无效的患儿,也可能是一种有效的治疗手段。The immune diseases of nervous system are a kind of nervous system diseases mediated by immune mechanism.High mortality and disability rates are its important characteristics. Early intervention and treatment can significantly improve the clinical outcomes of patients. At present, the main treatments for this kind of diseases include corticosteroid hormone, intravenous immunoglobulin(IVIG)and blood purification. Blood purification therapy has become the focus of current research because of its fast effect and other advantages.The main modes of blood purification therapy for this kind of diseases are plasma exchange and plasma immunoabsorption.Early application of blood purification therapy in patients with the acute attack and critical illness may lead to more significant clinical improvement. Therefore,blood purification may be an effective treatment for patients with the critical illness or when other medications are ineffective for the patients.

关 键 词：神经系统免疫性疾病 血浆置换 免疫吸附 时机 

分 类 号：R72[医药卫生—儿科]