血液净化在儿童急性肝功能衰竭中的应用  

Blood purification therapy in children with acute liver failure

作　　者：裴亮[1] 刘春峰[1] PEI Liang;LIU Chun-feng(Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿科重症监护病房

出　　处：《中国实用儿科杂志》2019年第12期1001-1005,共5页Chinese Journal of Practical Pediatrics

基　　金：辽宁省中央引导地方科技发展专项(2018108001);辽宁省重点研发计划指导计划项目(2017225003)

摘　　要：儿童急性肝功能衰竭(ALF)是儿科危重症,病死率高。体外肝脏支持系统包括生物型人工肝、非生物型人工肝和混合型人工肝,它可以为肝功能恢复创造机会或为肝移植治疗等待供肝赢得时间。非生物型人工肝的本质是血液净化,其已被证明可以改善患者的临床生化指标,但对于最终预后的影响不确定。与成人相比,儿科关于ALF的治疗数据较少,但近年来一些新的血液净化模式及组合式血液净化模式在ALF的治疗中显示了潜能,该文旨在介绍血液净化治疗儿童ALF的现状,为其治疗提供参考。Acute liver failure(ALF)is a life-threatening clinical syndrome in children,which has a high mortality. Extracorporeal liver support systems include bioartificial liver,nonbioartificial liver and hybrid artificial liver,with the aim of supporting children with ALF,as a bridge to recovery or liver transplantation. The theoretical basis of non-bioartificial liver support system is blood purification. Although biochemical efficacy has been demonstrated by these devices,the effect on the final prognosis has been unclear. Compared with adults,there are less data on the treatment for children with ALF,and some new blood purification modes and combined blood purification modes have shown potential in the treatment of ALF in recent years. The aim of this review is to introduce the practice of blood purification and to provide references for the treatment of children with ALF.

关 键 词：儿童 急性肝功能衰竭 血液净化 

分 类 号：R72[医药卫生—儿科]