中药促进牵张成骨的研究进展  

Progress of Chinese Medicine in Promoting Distraction Osteogenesis

作　　者：覃祥城 曾景奇 王凡 孙绍裘 QIN Xiang-Cheng;ZENG Jing-Qi;WANG Fan;SUN Shao-Qiu(The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005 Hunan,China)

机构地区：[1]湖南中医药大学第二附属医院

出　　处：《广州中医药大学学报》2020年第2期382-385,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：湖南省自然科学基金青年基金项目（编号：2018JJ3399）

摘　　要：牵张成骨(distraction osteogenesis,DO)已广泛应用于骨感染、骨缺损、骨肿瘤节段性截肢术后肢体畸形及肢体形态和功能重建,但该技术存在治疗周期过长、成骨质量不高等突出问题,这些问题成为制约牵张成骨技术推广应用的首要原因。已有实验研究结果证实三七、骨碎补、杜仲等活血化瘀、补肾强骨中药能通过调控牵张成骨中相关生长因子表达,加速牵张成骨区微循环和骨质钙化,最终促进新骨形成,具有提高牵张成骨的成骨质量、缩短治疗周期、提高成骨的效能;认为中药有望成为促进牵张成骨技术在临床推广应用的有效而可行的方法。Distraction osteogenesis(DO) has been widely used for the treatment of limb deformity and the morphological and functional reconstruction after segmental amputation in patients with bone infection, bone defect,or bone tumor. But for the disadvantages of long course of treatment and low-quality osteogenesis,the rapidly-expanding application of DO was restricted. Till now, the experimental study has proved that Chinese medicine such as Radix Notoginseng, Rhizoma Drynariae, and Cortex Eucommiae, which has the actions of activating blood and resolving blood stasis, tonifying kidney and strengthening bone, can accelerate the microcirculation and osteocalcification in the area of DO through regulating the expression of osteogenesis associated growth factors, so as to promote the formation of new bone, increase the quality of osteogenesis,shorten the course of treatment and increase the efficiency of osteogenesis. It is indicated that the application of Chinese medicine can be expected to be an effective and feasible method for promoting the rapidly-expanding application of DO in clinic.

关 键 词：牵张成骨 中药 骨感染 骨缺损 骨质钙化 新骨形成 综述 

分 类 号：R274.1[医药卫生—中医骨伤科学]