心脉通胶囊对高血脂大鼠的降脂作用  

Lipid-lowering Effect of Xinmaitong Capsule on Hyperlipidemia Rats

作　　者：付凌云 杨非 陈婷婷 陈妍 陶玲 沈祥春 徐旖旎 FU Lingyun;YANG Fei;CHEN Tingting;CHEN Yan;TAO Ling;SHEN Xiangchun;XU Yini(School of Pharmaceutic Sciences,Guizhou Medical University,Key Laboratory of Evaluation of Pharmacology and Patent Pharmacology of Natural Medicines in Universities of Guizhou,Key Laboratory of Optimal Utilization of Natural Medicine Resources,the High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州医科大学药学院,贵州省高等学校天然药物药理与成药性评价重点实验室,天然药物资源优效利用重点实验室,贵州省天然药物资源高效利用工程中心,贵州贵阳550025

出　　处：《贵州医科大学学报》2020年第1期35-38,44,共5页Journal of Guizhou Medical University

基　　金：贵州省科技创新团队项目[黔科合人才团队(2015)4025];贵州省高层次创新型人才百层次人才项目[黔科合人才(2015)4029];贵州医科大学药学国际科技合作基地[黔科合平台人才(2017)5802];贵州省科技厅支撑计划[黔科合支撑(2017)2834]

摘　　要：目的:研究心脉通胶囊(XMT)对高血脂大鼠的降脂作用。方法:取健康Sprague Dawley(SD)雄性大鼠60只(180~220 g),10只作为对照组采用全价颗粒饲料,其余50只大鼠采用高脂饲料喂养4周构建高血脂大鼠模型后,随机均分为模型组、XMT低剂量组(0.4 g/kg,XMT-L)、XMT中剂量组(0.8 g/kg,XMT-M)、XMT高剂量组(XMT-H,1.6 g/kg)和阳性组(山绿茶胶囊);各组大鼠连续口服灌胃相应药物(对照组和模型组灌胃生理盐水)第14天时大鼠股动脉取血,检测血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、白蛋白(ALB)、尿素氮(BUN)、血肌酐(CRE)及球蛋白(GLB)水平。结果:与对照组大鼠比较,模型组大鼠TC、TG和LDL-C增高,HDL-C降低(P<0.05或P<0.01);XMT-L组、XMT-M组及XMT-H组大鼠分别与模型组大鼠相比,TC、TG和LDL-C均有不同程度的降低,HDL-C增高(P<0.05或P<0.01);阳性组大鼠与模型组大鼠相比,TG降低,HDL-C增高(P<0.05);模型组大鼠与对照组大鼠相比,ALT、AST和TP增高,差异有统计学意义(P<0.05或P<0.01);与模型组比较,XMT-L组和XMT-M组大鼠ALT和AST降低,XMT-H组大鼠ALT、AST和TP均降低,差异有统计学意义(P<0.05或P<0.01);阳性药组大鼠与模型组大鼠相比,ALT和AST明显降低(P<0.01);各组大鼠间血清ALB、BUN、CRE及GLB差异均无统计学意义(P>0.05)。结论:XMT对高血脂大鼠具有降血脂作用,对其肝功能也具有一定的保护作用。Objective:To investigated the lipid-lowering effect of Xinmaitong Capsule on hyperlipidemia rats.Methods:60 healthy SD rat(180~220 g)were divided into control group(10,provided with normal pellet feed),model group provided with high fat diet for four weeks to build hyperlipidemia rat model(50);model group was further divided into five groups with equal number:model group,XMT low dose group(XMT-L 0.4 g/kg),XMT medium dose group(XMT-M 0.8 g/kg),XMT high dose group(XMT-H 1.6 g/kg),positive group(Shan lvcha capsule).After 14 d of treatment(all groups were given oral intragastric medicine,control group and model group were given saline).The rats were treated of Femoral artery blood to detection TG(triglyceride),TC(cholesterol),HDL-C(high density lipoprotein cholesterol),LDL-C(low density lipoprotein),ALT(alanine aminotransferase),AST(aspartate aminotransferase),TP(total protein),ALB(albumin),BUN(urea nitrogen),CRE(serum creatinine),GLB(globulin)index.Results:Compared with control group,the TG,TC and LDL-C were significant increased and HDL-C decreased in model group(P<0.05 or P<0.01).All XMT groups were compared with model group,the TG,TC and LDL-C were decreased in different degrees,while HDL-C increased(P<0.05 or P<0.01).Comparing positive group with model group,TG was lowered while HDL-C increased(P<0.05);comparing model group with control group,ALT,AST and TP all increased,differences were statistically significant(P<0.05 or P<0.01);compared with model group,XMT-L group and XMT-M group showed lowered ALT and AST,while XMT-H showed lowered ALT,AST and TP,differences were statistically significant(P<0.05 or P<0.01);comparing positive group and model group,ALT and AST were significantly lowered(P<0.01);the serum ALB,BUN,CRE,GLB were not statistically different in all groups(P>0.05).Conclusion:Xinmaitong Capsule showed lipid lowering effect on hyperlipidemia rats,and has certain protection effect on rats'liver function.

关 键 词：心血管疾病 甘油三酯类 胆固醇 脂蛋白类 HDL 脂蛋白类 LDL 血脂异常 心脉通胶囊 

分 类 号：R965.1[医药卫生—药理学]