中西医结合治疗伏格特-小柳-原田综合征临床疗效的Meta分析  

Meta-Analysis of Clinical Effect of Integrated Traditional Chinese and Western Medicine in Treating Vogt-Koyanagi-Harada Syndrome

作　　者：逯晶[1] 周静 谢城锋 黄博 吴雨洁 彭清华[3,4] LU Jing;ZHOU Jing;XIE Chengfeng;HUANG Bo;WU Yujie;PENG Qinghua(Medical School,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Chinese Medical School,Hunan University of Chinese Medicine,Changsha,Hunan 41O2O8,China;Key Disciplines of Traditional Chinese Medicine Ophthalmology in Hunan University of Chinese Medicine,Changsha,Hunan 41O2O8,China;Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine,Changsha,Hunan 41O2O8,China)

机构地区：[1]湖南中医药大学医学院,湖南长沙410208 [2]湖南中医药大学中医学院,湖南长沙410208 [3]湖南中医药大学中医眼科学重点学科,湖南长沙410208 [4]中医药防治眼耳鼻喉疾病湖南省重点实验室,湖南长沙410208

出　　处：《湖南中医药大学学报》2020年第1期80-86,共7页Journal of Hunan University of Chinese Medicine

基　　金：中医药防治五官科疾病湖南省重点实验室建设项目（2017TP1018）;湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心建设项目（2018TP2008）;湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心开放基金项目（2018YGC01）;湖南省自然科学基金资助项目（NO.2017JJ3249）;湖南省研究生科研创新项目（CX2018B461）;长沙市科技计划项目（kc1704005）;湖南省教育厅科学研究项目（18C0394）;湖南省大学生创新创业训练项目（1686）;中央财政支持地方高校建设项目;国家中医药管理局中医眼科学重点学科建设项目;湖南省中医五官科学重点学科建设项目

摘　　要：目的通过Meta分析系统评价中西医联合治疗伏格特-小柳-原田综合征(Vogt-Koyanagi-Harada syndrome,VKH综合征)的临床疗效。方法根据主题词检索中国知网(CNKI)、万方数据库、中国生物医学文献数据库以及美国国立医学图书馆等数据库中关于中西医联合治疗VKH综合征的中、英文文献。根据纳入与排除的标准以及参照改良后的JADAD量表对所检索的文献进行资料提取与质量的评价,并采用RevMan5.3软件对中西医联合治疗VKH综合征的疗效进行Meta分析。结果共纳入符合条件的文献8篇,共包含540例病例(1056只患眼),其中,治疗组288例(563只患眼),对照组252例(493只患眼)。比较了VKH综合征患者治疗组与对照组的以下临床指标:总有效率(OR=3.81,95%可信区间:[1.88,7.71])、复发率(OR=0.33,95%可信区间:[0.20,0.55])、治疗后视力变化(SMD=0.57,95%可信区间:[0.34,0.81])以及并发症发生率(OR=0.16,95%可信区间:[0.04,0.57])。结论与单纯西药治疗相比,中西医联合治疗VKH综合征具有有效率高、复发率低、视力改善更优以及并发症发生率低的优点。Objective To systematically evaluate the clinical efficacy of combined traditional Chinese and western medicine in the treatment of Vogt-Koyanagi-Harada(VKH)syndrome through meta-analysis.Methods The Chinese and English literature on the therapies of VKH syndrome by combination of traditional Chinese and western medicine were retrieved in CNKI database,Wanfang database,CBM database and PubMed database.According to the inclusion criteria,exclusion criteria and modified JADAD Manual,the data of the screened literature was extracted and the quality of screened literature was evaluated.The meta-analysis of the studies involved was carried out by Review Manager 5.3 software to compare the clinical outcome of combination of traditional Chinese and western medicine on the therapies of VKH syndrome.Results A total of 8 eligible trials were involved,including 540 patients(1056 eyes),with 288 patients(563 eyes)in the treatment group and 252 patients(493 eyes)in the control group.The efficacy index of VKH syndrome patients in the treatment group was compared with that in the control group:total effective rate(OR=3.81,95%CI:[1.88,7.71]),relapse rate(OR=0.33,95%CI:[0.20,0.55]),visual acuity changes(SMD=0.57,95%CI:[0.34,0.81]),complication rate(OR=0.16,95%CI:[0.04,0.57]).Conclusion Combined Chinese and western medicine in the treatment of VKH syndrome has obvious superiority over western medicine treatment alone,because of high clinical total effective rate,low relapse rate and better visual acuity changes and low complication rate.

关 键 词：VKH综合征 中西医结合疗法 META分析 

分 类 号：R276.7[医药卫生—中医五官科学]