有限内固定结合微型外固定架治疗对手部骨折患者血清OPG/RANK/RANKL水平的影响分析  

Effect of limited internal fixation combined with miniature external fixator on serum OPG/RANK/RANKL level in patients with hand fracture

作　　者：乔刚 郭铁[2] 宋海友 张楠 QIAO Gang;GUO Tie;SONG Haiyou;ZHANG Nan(Department of Orthopedics,Qinhuangdao Workers Hospital,Qinhuangdao 066200,Hebei,China;Department of Orthopedics,Xingtang County People s Hospital,Shijiazhuang 050600,Hebei,China)

机构地区：[1]秦皇岛市工人医院骨一科,河北秦皇岛066200 [2]行唐县人民医院骨科,河北石家庄050600

出　　处：《中南医学科学杂志》2020年第1期80-83,共4页Medical Science Journal of Central South China

基　　金：河北省卫生科技计划重点研究项目(20191363)

摘　　要：分析有限内固定结合微型外固定架治疗对手部骨折患者血清护骨素-核因子κB受体活化因子-核因子κB受体活化因子配体(OPG/RANK/RANKL)水平的影响。将86例手部关节内和关节周围骨折患者分为两组,观察组(n=43)患者接受有限内固定结合微型外固定架治疗,对照组(n=43)患者接受克氏针内与石膏固定治疗。治疗结果显示观察组患者的骨折愈合时间及不良反应发生率明显低于对照组而手指活动度优良率明显高于对照组(P<0.05);有限内固定结合微型外固定架治疗后患者血清中OPG水平明显升高(P<0.05)而C反应蛋白(CRP)、白细胞介素1β(IL-1β)、IL-2及RANK和RANKL水平明显降低(P<0.05),且与对照组患者相比,观察组患者的上述指标变化更显著(P<0.05)。实验表明有限内固定结合微型外固定架治疗能有效恢复手部骨折患者血清中异常的OPG/RANK/RANKL及炎症因子水平。To study the effect of limited internal fixation combined with miniature external fixator on serum OPG/RANK/RANKL level in patients with hand fracture.86 patients with intra-articular and peri-articular fractures were divided into two groups.The patients in the observation group(n=43)received limited internal fixation combined with miniature external fixator.The control group(n=43)received Kirschner wire and plaster fixation.The results showed that the healing time and incidence of adverse reactions in the observation group were significantly lower than those in the control group,and the excellent and good rate of finger movement was significantly higher than that in the control group(P<0.05).After limited internal fixation combined with mini external fixator treatment,the serum OPG level increased significantly(P<0.05),while CRP,IL-1beta,IL-2,RANK and RANKL levels decreased significantly(P<0.05).Compared with the control group,the changes of the above indexes in the observation group were more significant(P<0.05).So Limited internal fixation combined with miniature external fixator can effectively restore the abnormal levels of OPG/RANK/RANKL and inflammatory factors in the serum of patients with hand fracture.

关 键 词：有限内固定 微型外固定架 手部骨折 护骨素 核因子ΚB受体活化因子 核因子κB受体活化因子配体 炎症因子 

分 类 号：R683.41[医药卫生—骨科学]