小于胎龄儿母婴血浆中甜菜碱的水平及其与孕妇糖代谢的关系  

Maternal and Cord Blood Betaine Status in Small for Gestational Age Infants and Its Correlation with Glucose Metabolism

作　　者：翟笑 刘洁颖 李融融[3] 刘俊涛[4] 宋英娜[4] 马良坤[4] 乔宗旭[5] 赵贵芬[5] 王瑞平[5] 张茜 邓明群 付俊玲 周丽媛 赵楠[2] 宋玮[2] 肖新华 Zhai Xiao;Liu Jieying;Li Rongrong(Department of Endocrinology,Key Laboratory of Endocrinology,Ministry of Health,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院/北京协和医学院北京协和医院内分泌科、国家卫计委内分泌重点实验室,100730 [2]中国医学科学院/北京协和医学院北京协和医院中心试验室,100730 [3]中国医学科学院/北京协和医学院北京协和医院中心临床营养科,100730 [4]中国医学科学院/北京协和医学院北京协和医院中心妇产科,100730 [5]河北省邢台市人民医院妇产科,054001

出　　处：《医学研究杂志》2019年第12期36-40,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81570715、81870579、81870545);中央高校基本科研业务费专项资金资助项目(3332018015);中国医学科学院中央级公益性科研院所基本业务费资助项目(2017PT32020,2018PT32001)

摘　　要：目的探讨小于胎龄儿母婴血浆中甜菜碱的水平及其对糖代谢的影响。方法以15例小于胎龄儿(small for gestational age,SGA)及24例适于胎龄儿(appropriate for gestational age,AGA)的孕妇及新生儿为研究对象;采用液相质谱方法,检测两组孕妇外周血血浆及脐血血浆中的代谢物,发现两组血浆甜菜碱水平比较差异有统计学意义,同时进一步分析孕妇血浆甜菜碱水平与空腹胰岛素、HOMA-IR的相关性,以及脐血甜菜碱水平与新生儿体重的相关性。结果SGA组脐血甜菜碱水平明显高于AGA组(P=0.019),SGA组孕妇外周血甜菜碱水平较AGA组有升高趋势(P=0.094),脐血甜菜碱水平与新生儿出生体重呈明显负相关(r=-0.410,P=0.018)。孕妇孕晚期外周血甜菜碱水平与空腹胰岛素水平、HOMA-IR指数均呈明显负相关(r=-0.465,P=0.004;r=-0.548,P=0.000)。结论SGA组孕妇母婴甜菜碱水平均高于AGA组,脐血甜菜碱水平与出生体重呈负相关。Objective To investigate the level of maternal and cord blood betaine in SGA and AGA infants and the association between betaine status and glucose metabolism.Methods We recruited 128 pregnant and their newborns,and a total of 39 pairs of mothers and newborns were selected for plasma metabolomics analysis according to the birthweight of newborns,SGA(<10th percentile,n=15),AGA(10-50th percentile,n=24).The plasma levels of betaine in plasma and cord blood of the two groups were compared,and the correlation between cord blood betaine level and birth weight was analyzed.The plasma betaine level of mothers and its correlation with fasting insulin and HOMA-IR was analyzed.Theumbilical plasma betaine level and its correlation with birth weight was also analyzed.Results The umbilical cord blood betaine levels in the SGA group were significantly higher than those in the AGA group(P=0.019).The plasma betaine levels of mothers in the SGA group were higher than those in the AGA group(P=0.094).There was a significant negative correlation(r=-0.410,P=0.018)between cord blood betaine levels and neonatal birth weight.There was a significant negative correlation between betaine levels of mothers and their fasting insulin levels and HOMA-IR index(r=-0.465,P=0.004;r=-0.548,P=0.000).Conclusion The mother′s plasma and umbilical cord blood plasma betaine levels in the SGA group were higher than those in the AGA group,and the cord blood betaine level was negatively correlated with birth weight.

关 键 词：小于胎龄儿 甜菜碱 糖代谢 

分 类 号：R34[医药卫生—基础医学]