Silk Fibroin/Poly-L-lactide Lactone Bi-layered Membranes for Guided Bone Regeneration  

作　　者：WANG Linbo REN Xiangxiang JIANG Ziyi MENG Kai ZHAO Huijing 王临博;任翔翔;蒋紫仪;孟凯;赵荟菁(National Engineering Laboratory for Modern Silk,College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China;Nantong Textile&Silk Industrial Technology Research Institute,Nantong 226001,China)

机构地区：[1]National Engineering Laboratory for Modern Silk,College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China [2]Nantong Textile&Silk Industrial Technology Research Institute,Nantong 226001,China

出　　处：《Journal of Donghua University(English Edition)》2019年第6期564-572,共9页东华大学学报（英文版）

基　　金：Natural Science Foundation for Key Program of the Jiangsu Higher Education Institutions,China(No.19KJA610004);Natural Science Foundation of Jiangsu Province,China(No.BK20161254);China Postdoctoral Science Foundation(No.2019M651947);Mandatory Projects of Nantong Municipal Science and Technology Plan,China(No.JC2018004)

摘　　要：After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and atrophy.When the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant restoration.In order to control the absorption and promote the repair and regeneration of alveolar ridge,a method of implanting guided bone regeneration(GBR)membranes at the extraction site is often used.In this study,silk fibroin(SF)and poly-L-lactide lactone(PLCL)were used to prepare bilayered guided bone regeneration membranes,and its morphology,hydrophilicity,surface roughness and mechanical properties were studied.At the same time,the drug release behaviors and cell compatibility of the bilayered membranes were studied.The results showed that SF/PLCL bi-layered membranes had good mechanical properties and surface hydrophilicity,and the drug-loaded bi-layered membranes had good cell compatibility.The bilayered membranes fabricated in this study are of potential for applying in the oral health field to promote bone regeneration.After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and atrophy.When the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant restoration.In order to control the absorption and promote the repair and regeneration of alveolar ridge,a method of implanting guided bone regeneration(GBR) membranes at the extraction site is often used.In this study,silk fibroin(SF)and poly-L-lactide lactone(PLCL) were used to prepare bilayered guided bone regeneration membranes,and its morphology,hydrophilicity,surface roughness and mechanical properties were studied.At the same time,the drug release behaviors and cell compatibility of the bilayered membranes were studied.The results showed that SF/PLCL bi-layered membranes had good mechanical properties and surface hydrophilicity,and the drug-loaded bi-layered membranes had good cell compatibility.The bilayered membranes fabricated in this study are of potential for applying in the oral health field to promote bone regeneration.

关 键 词：SILK fibroin(SF) POLY-L-LACTIDE lactone(PLCL) guided bone regeneration(GBR) ORAL health 

分 类 号：TS101.4[轻工技术与工程—纺织工程]