重组人酸性成纤维细胞生长因子联合超脉冲二氧化碳激光治疗色素痣的临床疗效观察  

Effects of recombinant human acidic fibroblast growth factor(rh-aFGF)combined with ultrapulse carbon dioxide laser in the treatment of pigmented nevus

作　　者：孙赛[1] 张碧芳[1] 陈容容[1] 夏学颖[1] SUN Sai;ZHANG Bifang;CHEN Rongrong;XIA Xueying(Department of Plastic Surgery,Guangdong Maternal and Child Health Hospital,Guangdong,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院整形美容科

出　　处：《中国医药科学》2019年第24期65-68,共4页China Medicine And Pharmacy

基　　金：广东省科技计划项目(2016ZC0184)

摘　　要：目的观察重组人酸性成纤维细胞生长因子(rh-aFGF)在超脉冲二氧化碳激光治疗色素痣术后对创面愈合的影响。方法选取2018年3月~2019年3月我院因色素痣就诊的患者200例,随机分成观察组和对照组,每组100例。观察组予超脉冲二氧化碳激光联合重组人酸性成纤维细胞生长因子(rh-aFGF),对照组予超脉冲二氧化碳激光联合生理盐水。两组均外用盐酸金霉素眼膏预防创面感染7d。观察比较两组术后疗效及不良反应情况。结果两组治疗后即刻无差异,湿敷后、术后1周、术后3月观察组治疗局部创面恢复情况均明显优于对照组,差异有统计学意义(P<0.05)。术后3月观察组创面修复显著72例,占72%,总有效率为85%;对照组修复显著20例,占20%,总有效率为55%。观察组总有效率明显高于对照组(P<0.05)。观察组出现3例瘢痕增生,分别位于上唇1例,颈部2例;对照组出现2例瘢痕增生,均位于上唇。两组患者瘢痕增生比较差异无统计学意义(P>0.05)。结论二氧化碳激光治疗色素痣术后应用重组人酸性成纤维细胞生长因子(rh-aFGF)对促进创面愈合疗效明显,可有效降低激光术后色素沉着及凹陷性瘢痕形成几率。Objective To observe the effect of recombinant human acidic fibroblast growth factor(rh-aFGF)on wound healing after the treatment of pigmented nevus with ultrapulse carbon dioxide(CO2)laser.Methods 200 patients with pigmented nevus treated in our hospital from March 2018 to March 2019 were randomly divided into observation group and control group,with 100 cases in each group.The observation group was treated with CO2 laser and rh-aFGF,while the control group was treated with CO2 laser and normal saline.Both groups were treated with chlortetracycline hydrochloride eye ointment for preventing wound infection for 7 days.The curative effect and adverse reactions after treatment were observed and compared between the two groups.Results There was no difference in initial effects between the two groups.The recovery of local wound in the observation group after wet compress,1 week after operation and 3 months after operation was significantly better than the control group(P<0.05).3 months after operation,72 cases in the observation group were repaired significantly,accounting for 72%,with a total effective rate of 85%;20 cases in the control group were repaired significantly,accounting for 20%,with a total effective rate of 55%.The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There were 3 cases of scar hyperplasia in the observation group,with 1 on the upper lip,and 2 on the neck;and 2 cases of scar hyperplasia in the control group with all distributed on the upper lip.There were no significant differences in scar hyperplasia between the two groups(P>0.05).Conclusion The application of rh-aFGF after CO2 laser treatment of pigmented nevus has a significant effect on promoting wound healing,and can effectively reduce the incidence of hyperpigmentation and depressed scar.

关 键 词：重组人酸性成纤维细胞生长因子 超脉冲二氧化碳激光 色素痣 瘢痕 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]