2015年版中国药典含黄连成方制剂的统计分析及黄连提取工艺的试验研究  

Statistical Analysis and Experimental Study on the Extraction Process of Rhizoma Coptidis for The Preparation in 2015 edition of “Chinese Pharmacopoeia”

作　　者：张大军[1] 王兆华[1] Zhang Dajun;Wang Zhaohua(Academy of Chinese Medical Sciences of Jilin Province,Changchun 130012,China)

机构地区：[1]吉林省中医药科学院

出　　处：《山东化工》2020年第1期67-68,70,共3页Shandong Chemical Industry

基　　金：国家重大新药创制(2017ZX09301031)

摘　　要：本文一方面从剂型、制备方法上,对2015年版《中国药典》(一部)含黄连的成方制剂进行统计分析,发现该类制剂共有91种,剂型大多为丸剂(40种)、片剂(18种)和胶囊剂(17种);制备方法大多采用粉碎(66种),其次采用水煎法(17种)、再次采用醇提取(8种);另一方面,采用液相色谱法对不同工艺制得的黄连提取物进行表小檗碱、盐酸黄连碱、盐酸巴马汀、盐酸小檗碱的含量测定,为有效使用黄连提供理论依据。Statistical analysis of 2015 edition of"Chinese Pharmacopoeia" (Part Ⅰ) containing Rhizoma Coptidis was carried out from the formulation and preparation methods. 91 kinds of preparations was found,and pills (40 kinds),Tablets (18 kinds) and capsules (17 kinds) are most forms. Pulverization (66 kinds),water decoction (17 kinds) and alcohol extraction (8 kinds) are most preparation methods;content determination by HPLC extracts Rhizoma Coptidis obtained by different processes for epiberberine,coptisine hydrochloride,palmatine hydrochloride and berberine hydrochloride,providing a effective theoretical basis for Rhizoma Coptidis use.

关 键 词：2015年版《中国药典》(一部) 黄连 成方制剂 提取物 含量测定 

分 类 号：O657.7[理学—分析化学]