慢性乙型肝炎病毒感染患者睡眠情况调查  

Sleep Status of Patients with Chronic Hepatitis B Virus Infection

作　　者：郑小燕[1] 于明雪 揭育胜[1] 曹静 沙柳平 崇雨田[1] 张宇锋[1] 王继辉[2] ZHENG Xiao-yan;YU Ming-xue;JIE Yu-sheng;CAO Jing;SHA Liu-ping;CHONG Yu-tian;ZHANG Yu-feng;WANG Ji-hui(Department of Infectious Disease,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510530,China;Department of Psychiatry,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510530,China)

机构地区：[1]中山大学附属第三医院感染科,广东广州510630 [2]中山大学附属第三医院精神//心理科,广东广州510630

出　　处：《中山大学学报（医学版）》2020年第1期95-102,共8页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家“十三五”科技重大专项(2018ZX10715004-001);5010计划常规项目(2016009);广东省自然科学基金(2018A030310272);广东医学科学基金(A2018366)

摘　　要：【目的】调查慢性乙型肝炎病毒感染患者的主观睡眠现状。【方法】以2019年1月至6月中山大学附属第三医院门诊慢性乙型肝炎病毒感染患者353例,采用嗜睡量表、失眠程度量表、睡眠质量量表、焦虑自评表和抑郁自评表对患者进行评分,并按照睡眠情况分级标准进行分组,收集患者性别、年龄、疾病诊断、是否抗病毒治疗及文化程度资料,通过卡方检验及多因素logistic回归分析睡眠情况的影响因素。【结果】慢性乙型肝炎病毒感染患者总体嗜睡率为47.88%,总体失眠率为53.26%,6.8%的患者睡眠质量很差。嗜睡的危险因素为焦虑(P=0.000,OR=3.076,95%CI 1.706~5.545),失眠的危险因素为焦虑(P=0.000,OR=14.693,95%CI 5.046~42.782及抑郁(P=0.002,OR=2.279,95%CI 1.340~3.877),睡眠质量差的危险因素为焦虑(P=0.000,OR=9.990,95%CI 4.031~24.758)。【结论】慢性HBV感染患者出现主观睡眠障碍比例高,影响睡眠情况的主要因素为患者的心理状态,充分了解患者睡眠情况将有助于临床治疗。【Objective】To investigate the sleep status of patients with chronic HBV infection【Methods】From Janu⁃ary 2019 to June 2019,353 patients with chronic hepatitis B virus infection in the outpatient department of The Third Affiliated Hospital of Sun Yat-sen University,using the sleepiness scale,insomnia scale,sleep quality scale,anxiety self-rating form and depression self-evaluation,patients were scored and grouped according to sleep grading criteria.Patients were collected for gender,age,disease diagnosis,antiviral therapy,and educational level.Chi-square correlation test and multivariate logistic regression were applied to analyze the influencing factors of sleep.【Results】The overall sleepiness rate was 47.88%.The overall insomnia rate was 53.26%.There were 6.8%patients who had poor sleep quality.The risk factor of lethargy was the degree of anxiety(P=0.000,OR=3.076,95%CI 1.706~5.545).The risk factor of in⁃somnia was anxiety(P=0.000,OR=14.693,95%CI 5.046~42.782)and depression(P=0.002,OR=2.279,95%CI 1.340~3.877).The risk factor of sleep quality was anxiety(P=0.000,OR=9.990,95%CI 4.031~24.758).【Conclusions】Patients with chronic HBV infection have a high proportion of subjective sleep disorders.The main influencing factor is mental state of the patient.A full understanding of the patients′sleep status will help the patients′treatment.

关 键 词：HBV 睡眠障碍 调查 

分 类 号：R512.6[医药卫生—内科学]