知柏地黄丸辅助治疗儿童中枢性性早熟有效性和安全性的系统评价  

Systematic Review on Effectiveness and Safety of Zhibai Dihuang Pills in the Adjuvant Treatment of Children’s Central Precocious Puberty

作　　者：傅倩云 梁家红[1] 戴燕青[1] 方罗 吴妙莲[1] 高向波[1] 黄梦珊[1] 蔡志波[1] FU Qianyun;LIANG Jiahong;DAI Yanqing;FANG Luo;WU Miaolian;GAO Xiangbo;HUANG Mengshan;CAI Zhibo(Department of Pharmacy,the Children’s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属儿童医院药剂科国家儿童健康与疾病临床医学研究中心

出　　处：《中国现代应用药学》2020年第1期85-90,共6页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的系统评价知柏地黄丸辅助治疗儿童中枢性性早熟(central precocious puberty,CPP)的有效性和安全性。方法通过检索Embase、Web of Science、Pubmed、Cochrane Library、CNKI、万方数据库、VIP数据库,根据纳入标准收集知柏地黄丸辅助治疗儿童CPP的随机对照试验文献,利用RevMan 5.3软件进行meta分析。结果共有10篇文献符合纳入标准,总例数862例。Meta分析结果显示,知柏地黄丸不论与其他中成药或者西药联合治疗儿童CPP的临床疗效均高于促性腺激素释放激素拟似药(gonadotropin-releasing hormone analogue,GnRH-a)单独治疗。知柏地黄丸与GnRH-a联合治疗在抑制骨龄和血清促黄体生成素水平上与GnRH-a单独治疗相比无优势,而在减缓子宫、卵巢、卵泡的发育和抑制血清促卵泡激素水平上的疗效更佳。同时,联合治疗可缩短疗程,减轻患者的经济负担。结论知柏地黄丸辅助治疗儿童CPP安全有效。OBJECTIVE To systemically review the effectiveness and safety of Zhibai Dihuang pills(ZDP)in the adjuvant treatment of central precocious puberty(CPP)in children.METHODS The databases of Embase,Web of Science,Pubmed,Cochrane Libray,CNKI,Wan Fang,and VIP were retrieved for collecting the randomized controlled trial(RCT)about the adjuvant treatment of CPP in children with ZDP.All the meta-analyses were performed by RevMan 5.3.RESULTS Ten RCTs were included and totally 862 patients.Meta-analysis showed that ZDP were superior to GnRH-a alone in the treatment of CPP whether combined with other proprietary Chinese medicines or western medicines.ZDP combined with gonadotropin-releasing hormone analogue(GnRH-a)had no advantage in inhibiting bone age and the content of luteinizing hormone levels in serum,but it was better in slowing the development level of the uterus,ovarian,follicular and inhibiting the level of follicle stimulating hormone in serum compared with GnRH-a alone.The combined therapy could shorten the course of treatment and reduce the economic burden of patients.CONCLUSION It’s safe and reliable in the adjuvant treatment of CPP in children with ZDP.

关 键 词：知柏地黄丸 中枢性性早熟 儿童 META分析 

分 类 号：R969.4[医药卫生—药理学]