接骨丹对自体肌腱重建前交叉韧带术后关节功能及TNF-α、IL-1β、MMP-2表达的影响  

The effect of Jiegudan on the postoperative recovery after anterior cruciate ligament reconstruction by autologous tendon and the expression of TNF-α,IL-1β,and MMP-2

作　　者：林石明[1] 司在武 吴平 梁辉[1] 欧清彬 杨国宗[1] Lin Shiming;Si Zaiwu;Wu Ping;Liang Hui;Ou Qingbin;Yang Guozong(Department of Orthopaedics,Zhangzhou Hospital of Traditional Chinese Medicine,Fujian 363000,China)

机构地区：[1]漳州市中医院骨科,363000

出　　处：《国际医药卫生导报》2020年第1期21-26,共6页International Medicine and Health Guidance News

基　　金：福建省中医药科研课题(wzgs201310)。

摘　　要：目的探讨接骨丹对前交叉韧带重建术后关节功能恢复及腱-骨愈合中TNF-α、IL-1β、MMP-2表达的影响。方法选取本院2014年6月至2016年5月收治的前交叉韧带重建术的患者共60例。随机分为观察组与对照组,各30例。2周内两组患者术后常规进行膝关节康复功能锻炼及口服消肿活血方,观察组第3周开始口服接骨丹,连续服药4周,中间休息1周后继续服药4周。对两组患者治疗前后关节功能评分、关节液及血液中炎性介质因子进行比较。结果术前、术后3个月、术后6个月Lysholm评分观察组分别为(38.37±1.10)分、(85.01±2.34)分、(93.37±1.30)分,对照组分别为(38.90±1.27)分、(81.10±2.89)分、(93.87±1.57)分,术后3个月两组比较差异有统计学意义(P<0.05);术前、术后1个月、术后3个月关节液中IL-1β含量观察组分别是(142.67±16.96)pg/nl、(99.81±17.53)pg/nl、(34.74±6.58)pg/nl,对照组分别是(145.55±17.50)pg/nl、(110.24±18.04)pg/nl、(38.87±7.44)pg/nl,术后1个月、术后3个月两组比较差异均有统计学意义(均P<0.05);关节液中TNF-α含量观察组分别是(249.50±18.70)pg/nl、(122.13±19.81)pg/nl、(60.42±9.53)pg/nl,对照组分别是(241.80±21.08)pg/nl、(135.61±17.70)pg/nl、(66.20±12.35)pg/nl,术后1个月、术后3个月两组比较差异均有统计学意义(均P<0.05);关节液中MMP-2含量观察组分别是(102.36±12.10)pg/nl、(80.16±9.35)pg/nl、(63.28±13.74)pg/nl,对照组分别是(98.29±11.13)pg/nl、(91.02±14.97)pg/nl、(67.81±16.36)pg/nl,术后1个月两组比较差异有统计学意义(P<0.05);术前、术后1个月、术后3个月血液中IL-1β含量观察组分别是(213.46±18.31)pg/nl、(139.61±17.46)pg/nl、(103.88±17.92)pg/nl,对照组分别是(211.60±15.02)pg/nl、(149.92±15.96)pg/nl、(100.96±13.32)pg/nl,术后1个月、术后3个月两组比较差异有统计学意义(P<0.05);血液中TNF-α含量观察组分别是(352.44±24.70)pg/nl、(240.65±22.26)pg/nl、(131.80±17.27)pg/nl,�Objective To investigate the effect of Jiegudan on the postoperative recovery after anterior cruciate ligament reconstruction by autologous tendon and the expression of TNF-α,IL-1β,and MMP-2 during the tendon-bone healing.Methods 60 patients with anterior cruciate ligament reconstruction in our hospital from June 2014 to May 2016 were selected.They were randomly divided into observation group and control group,30 cases in each group.Within 2 weeks,the two groups of patients underwent routine knee rehabilitation exercise and oral Xiaozhong Huoxue herb.The observation group began to use Jiegudan from the third week after operation,and took the drug for 8 weeks with 1 week of interval in the middle.Results The Lysholm scores in the observation group before operation,3 months after operation,and 6 months after operation were(38.37±1.10),(85.01±2.34),(93.37±1.30),and those in the control group were(38.90±1.27),(81.10±2.89),(93.87±1.57),the difference was statistically significant at 3 months after operation(P<0.05).The content of IL-1β in the synovial fluid in the observation group before operation,1 month after operation,and 3 months after operation were(142.67±16.96)pg/nl,(99.81±17.53)pg/nl,(34.74±6.58)pg/nl,and those in the control group were(145.55±17.50)pg/nl,(110.24±18.04)pg/nl,(38.87±7.44)pg/nl,the difference between the two groups was statistically significant at 1 month and 3 months after operation(P<0.05).The levels of TNF-α in the synovial fluid in the observation group before operation,1 month after operation,and 3 months after operation were(249.50±18.7)pg/nl,(122.13±19.81)pg/nl,(60.42±9.53)pg/nl,and those in the control group were(241.80±21.08)pg/nl,(135.61±17.70)pg/nl,(66.20±12.35)pg/nl,the difference between the two groups was statistically significant at 1 month and 3 months after operation(P<0.05).The levels of MMP-2 in the synovial fluid in the observation group before operation,1 month after operation,and 3 months after operation were(102.36±12.10)pg/nl,(80.16±9.35)pg/nl,(63

关 键 词：接骨丹 前交叉韧带 重建 TNF-α IL-1Β MMP-2 

分 类 号：R687[医药卫生—骨科学]