弓形虫感染对神经组织损伤及通过血脑屏障机制  

Toxoplasma Infection on Nerve Tissue Damage and Its Mechanism through the Blood-Brain Barrier

作　　者：杨靖 苑文英[1] YANG Jing;YUAN Wen-ying(Hebei University,Baoding,071000,China)

机构地区：[1]河北大学

出　　处：《神经药理学报》2019年第5期40-43,共4页Acta Neuropharmacologica

摘　　要：刚地弓形虫是一种专性细胞内寄生原虫,可入侵几乎所有的有核细胞,虫体进入机体随血液循环散播到全身组织和器官,引起弓形虫病。弓形虫对神经组织具有亲嗜性,引起中枢神经系统异常,常表现为脑炎、脑膜脑炎、癫痫和精神异常等症状。弓形虫对神经组织的损伤一直被人们广泛关注。血脑屏障是脑组织与外界进行物质交流的场所,其独特的构造在一定程度上延迟或阻隔了弓形虫入侵大脑的过程,但弓形虫仍然通过了血脑屏障入侵中枢神经系统,造成宿主脑组织细胞损伤,该文就弓形虫对中枢神经系统的损伤和通过血脑屏障的机制进行了阐述。Toxoplasma gondii is an obligate intracellular parasitic protozoa that invades almost all nucleated cells. The worm enters the body and spreads to the tissues and organs along with blood circulation,causing toxoplasmosis. Toxoplasma gondii has a tropism on nerve tissue,causing abnormalities in the central nervous system,often manifested as encephalitis,meningoencephalitis,epilepsy and mental disorders. The damage of Toxoplasma gondii to nerve tissue has been widely concerned. The blood-brain barrier is a place where the brain tissue communicates with the outside world. Its unique structure delays or blocks the process of Toxoplasma gondii invasion into the brain to a certain extent,but Toxoplasma gondii still invades the central nervous system through the blood-brain barrier,causing the tissue cell damage in host brain. This paper describes the damage of Toxoplasma gondii to the central nervous system and the mechanism through the blood-brain barrier.

关 键 词：刚地弓形虫 血脑屏障 中枢神经系统 损伤机制 

分 类 号：S852.7[农业科学—基础兽医学]