内皮素与高血压肾损害的关系研究进展  

Research progress of the relationship between endothelin and hypertensive renal damage

作　　者：张婷 刘寻 王晓菲 逯小英 邹洪斌[1] Zhang Ting;Liu Xun;Wang Xiaofei;Lu Xiaoying;Zou Hongbin(Department of Nephrology,Second Hospital of Jilin University,Changchun 130000,Jilin Province,China)

机构地区：[1]吉林大学第二医院肾内科

出　　处：《中华肾病研究电子杂志》2019年第6期273-276,共4页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：高血压肾损害是指由原发性高血压引起的肾脏结构和功能损害,高血压和肾脏损害两者之间互为因果,相互促进病变发展。内皮素(ET)系统可通过各种机制调控血压及肾脏血流,与高血压肾损害的发生、发展有着密切联系。而内皮素受体拮抗剂(ERAs)则可通过作用于内皮素受体(ETRs),阻断内皮素的效应,从而降低血压,改善肾功能,延缓高血压肾损害的进展。Hypertensive renal damage refers to renal structural and functional damage caused by essential hypertension.Hypertension and renal damage are causal to each other and promote the development of pathological changes.Endothelin(ET)system can regulate blood pressure and renal blood flow through various mechanisms,which is closely related to the occurrence and development of hypertensive renal damage.Endothelin receptors antagonists(ERAs)can block the effect of endothelin by acting on endothelin receptors(ETRs),thereby lowering blood pressure,improving renal function,and delaying the progression of hypertensive renal damage.

关 键 词：内皮素 内皮素受体拮抗剂 高血压肾损害 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]