呼吸道合胞病毒及其感染相关TLRs的研究进展  

Advances in respiratory syncytial virus and its infection-related Toll-like receptors

作　　者：杜海涛 孙铁锋[2] 王平[2,3] 安丰田 胡亚楠[1] 李娜 DU Hai-tao;SUN Tie-feng;WANG Ping;AN Feng-tian;HU Ya-nan;LI Na(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Academy of Chinese Medicine,Jinan 250014,China;State Key Laboratory of Precision Measurement Technology and Instruments,Tianjin University,Tianjin 300072,China;Pharmaceutical Department of Qingdao Municipal Hospital,Qingdao 266011,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东省中医药研究院,山东济南250014 [3]天津大学精密测试技术及仪器国家重点实验室,天津300072 [4]青岛市市立医院药学部,山东青岛266011

出　　处：《山东科学》2020年第1期42-50,共9页Shandong Science

基　　金：山东省重大科技创新工程(2018CXGC1310);山东省重点研发计划(重大关键技术)(2017CXGC1306,2016ZDJS07A23);山东省重点研发计划(2015GSF119014,2016GSF202042);山东省中医药科技发展计划(2011-154)

摘　　要：呼吸道合胞病毒(respiratory syncytial virus,RSV)是婴幼儿呼吸道感染的主要原因,Toll样受体(Toll-like receptors,TLRs)是参与固有免疫的模式识别受体,在识别与清除RSV过程中发挥重要作用。当前对此研究尚不明确,限制了抗病毒药物和疫苗研发的进程。本研究就近年与RSV相关TLRs免疫过程研究展开综述,提出当前研究在方法和方向上存在的不足,为下一步开展抗RSV新药及其机制研究提供思路和方法。Respiratory syncytial virus( RSV) is the leading cause of respiratory tract infections in infants. Toll-like receptors,one of the pattern recognition receptors involved in innate immunity,play an important role in the identification and eradication of RSVs. However,this is not adequately examined,which has limited the development of antiviral drugs and vaccines. In this study,we reviewed the studies on the immunologic process of RSV-related Toll-like receptors in recent years and described the shortcomings of the methods and tendencies of the current studies. This is intended to provide ideas and methods for the further studies on new anti-RSV drugs and their mechanisms.

关 键 词：呼吸道合胞病毒 TOLL样受体 机制 抗病毒 

分 类 号：R289[医药卫生—方剂学]