广州地区健康人群胃蛋白酶原参考范围的建立  

Establishment of pepsinogen reference intervals among healthy population in Guangzhou area

作　　者：汪杨 李溪 梁志伟[1] 朱晔[1] 卢卫国[1] 周迎春[1] WANG Yang;LI Xi;LIANG Zhiwei;ZHU Ye;LU Weiguo;ZHOU Yingchun(Department of Clinical Laboratory,First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510405,China)

机构地区：[1]广州中医药大学第一附属医院检验科

出　　处：《检验医学与临床》2020年第4期433-435,共3页Laboratory Medicine and Clinic

基　　金：广东省教育厅科技创新重点项目(2017KZDXM019)

摘　　要：目的基于化学发光微粒子免疫测定法建立广州地区健康体检人群胃蛋白酶原(PG)的参考范围。方法收集广州地区健康体检者共4 108例血清标本,检测PGⅠ和PGⅡ,并计算PGⅠ/PGⅡ。结果广州地区的健康成年居民血清PGⅠ、PGⅡ及PGⅠ/PGⅡ均呈偏态分布,PGⅠ/PGⅡ和年龄呈负相关性。男性的PGⅠ、PGⅡ和PGⅠ/PGⅡ的数值比女性高,男性和女性的PGⅠ和PGⅡ在≤40岁、>40~50岁和>50岁这3个年龄段分别建立不同的参考范围。PGⅠ/PGⅡ男性参考范围为≥3.72,女性为≥3.15。结论分别依据性别和年龄段建立了广州地区健康体检人群PG参考范围,为临床进一步研究打下基础。Objective To establish the pepsinogen (PG) reference intervals (RIs) among the healthy population in Guangzhou area based on the chemiluminescence microparticle immunoassay.Methods A total of4 108 cases of serum sample from the people undergoing healthy physical examination in Guangzhou area were collected.The values of PGⅠ and PGⅡ were detected and the value of PG Ⅰ/PG Ⅱ was calculated.Results The values of serum PGⅠ,PGⅡand PGⅠ/PGⅡamong healthy adult residents in Guangzhou area showed the skewed distribution,and the PGⅠ/PGⅡratio was negatively correlated with the age.The values of PGⅠ,PGⅡand PGⅠ/PGⅡin males were higher than those in females.RIs of PGⅠ and PGⅡ of males and females were established in the three age groups of≤40 years old,>40-50 years old and>50 years old respectively.RIs of PGⅠ/PGⅡ was≥3.72 in male and≥3.15 in female.Conclusion RIs of PG among healthy population of Guangzhou area are established according to the sex and age groups,which lays a foundation for future clinical studies.

关 键 词：胃蛋白酶原 健康人群 参考范围 

分 类 号：R446.61[医药卫生—诊断学]