雌激素联合甲硝唑阴道给药治疗萎缩性阴道炎的临床效果  

The Effect of Estrogen Combined with Metronidazole in the Treatment of Atrophic Vaginitis

作　　者：陆燕[1] LU Yan(Xiaogan Hospital Affiliated to Wuhan University of Science and Technology,Xiaogan 432000,China)

机构地区：[1]武汉科技大学附属孝感医院

出　　处：《中国医学创新》2019年第35期125-128,共4页Medical Innovation of China

摘　　要：目的:研究雌激素联合甲硝唑阴道给药治疗萎缩性阴道炎的临床效果。方法:选择2017年1月-2018年9月本院妇科收治的100例萎缩性阴道炎患者,按照随机数字表法分为对照组与观察组,各50例。对照组给予甲硝唑栓阴道给药治疗,观察组在对照组基础上加用雌激素治疗。比较两组临床疗效、症状改善情况、血清炎症因子水平、阴道内环境指标、生活质量评分、不良反应发生率、复发率。结果:观察组临床总有效率高于对照组(P<0.05),观察组的白带减少时间、外阴瘙痒消失时间、黏膜充血消失时间均短于对照组(P<0.05)。治疗后,观察组的CRP、IL-6水平、阴道p H值、清洁度评分均低于对照组(P<0.05),生活质量各项评分均高于对照组(P<0.05)。观察组的不良反应发生率为4.00%,与对照组的2.00%比较,差异无统计学意义(P>0.05)。随访6个月,观察组的复发率为2.00%,低于对照组的14.00%(P<0.05)。结论:雌激素联合甲硝唑可提高萎缩性阴道炎患者的临床疗效,缓解其症状,减轻炎症反应,改善阴道内环境,有利于提高其生活质量水平,减少复发,且不会增加不良反应发生率,安全性良好。Objective:To investigate the clinical efficacy of Estrogen combined with Metronidazole in the treatment of atrophic vaginitis.Method:A total of 100 patients with atrophic vaginitisin in our hospital of department of gynaecology from January 2017 to September 2018 were selected,they were divided into control group and observation group,50 cases in each group.The control group was treated with Metronidazole Suppositories,and the observation group was treated with Estrogen on the basis of the control group.The clinical effect,symptom improvement,serum inflammatory factor level,internal vaginal environment index,quality of life score,incidence of adverse reactions and recurrence rate of the two groups were compared.Result:The total clinical effective rate of the observation group was higher than that of the control group(P<0.05),and the time of leucorrhea reduction,pruritus disappearance and mucosal congestion disappearance in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of CRP,IL-6,vaginal pH and cleanliness in the observation group were lower than those in the control group(P<0.05),and life quality scores were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.00%,compared with 2.00% in the control group,the difference was not statistically significant(P>0.05).The recurrence rate of the observation group was 2.00%,lower than 14.00%of the control group(P<0.05).Conclusion:Estrogen combined with Metronidazole can improve the clinical efficacy of atrophic vaginitis patients,alleviate their symptoms,reduce the inflammatory reaction,improve the internal environment of vagina,improve their quality of life,reduce recurrence,and will not increase the incidence of adverse reactions,good safety.

关 键 词：妇科 萎缩性阴道炎 甲硝唑 雌激素 

分 类 号：R711.31[医药卫生—妇产科学]