黄疸新生儿TORCH特异性抗体检测的临床应用  

Clinical Application of Torch Specific Antibody Detection in Jaundice Newborn

作　　者：林燕[1] 聂宇波[1] 戴薇[1] 宋丽云 LIN Yan;NIE Yubo;DAI Wei;SONG Liyun(Ganzhou People’s Hospital,Ganzhou 341000,China)

机构地区：[1]江西省赣州市人民医院

出　　处：《中国医学创新》2019年第36期159-162,共4页Medical Innovation of China

基　　金：赣州市指导性科技计划项目（GZ2017ZSF160）

摘　　要：目的:探讨黄疸新生儿TORCH特异性抗体检测的临床应用。方法:选取2017年1月-2018年12月在本院出生的病理性黄疸新生儿60例为黄疸组,并以同期健康新生儿60例为健康组。比较两组TORCH-IgM抗体和TORCH-IgG抗体阳性表达率及血清胆红素水平(TBIL、IBIL、DBIL);比较黄疸组TORCH-IgG抗体不同表达水平者血清胆红素水平;分析TORCH-IgM抗体及TORCH-IgG抗体阳性表达与病理性黄疸发生的相关性;分析TORCH-IgG抗体表达与血清胆红素水平的相关性。结果:黄疸组TOX-IgG、RV-IgG、CMV-IgG抗体阳性表达率均高于健康组(P<0.05);两组TORCH-IgM抗体阳性表达率及HSV-IgG抗体阳性表达比较,差异均无统计学意义(P>0.05);TORCH-IgG抗体阳性表达组血清TBIL、IBIL均高于阴性组(P<0.05),两组DBIL水平比较,差异无统计学意义(P>0.05);经Pearson检验分析,TORCH-IgG抗体表达与TBIL、IBIL、DBIL水平均呈正相关(P<0.05);经Spearman检验分析,TORCH-IgM抗体阳性表达与病理性黄疸发生无相关性(P>0.05),TORCH-IgG抗体阳性表达与病理性黄疸发生呈正相关(P<0.05)。结论:黄疸新生儿TORCH-IgG抗体阳性表达率高于健康新生儿,其TORCH-IgG特异性抗体表达与黄疸的发生及严重程度有关。Objective:To investigate the clinical application of TORCH specific antibody in jaundice neonates.Method:A total of 60 neonates with pathological jaundice born in our hospital from January 2017 to December 2018 were selected as jaundice group,and 60 healthy newborns in the same period were selected as healthy group.The positive expression rate of TORCH-IgM antibody and TORCH-IgG antibody and serum bilirubin levels(TBIL,IBIL,DBIL)were compared between the two groups.The serum bilirubin levels of patients with different TORCH-IgG antibody expression levels in jaundice group were compared.The correlation between the expression of TORCH-IgM antibody and TORCH-IgG antibody and pathological jaundice were analyzed.The correlation between TORCH-IgG antibody expression and serum bilirubin level was analyzed.Result:The positive expression rate of TOX-IgG,RV-IgG and CMV-IgG in the jaundice group were higher than those in the healthy group(P<0.05).There were no significant differences in the positive expression rate of TORCH-IgM antibody and HSV-IgG antibody between the two groups(P>0.05).Serum TBIL and IBIL in the TORCH-IgG positive expression group were higher than those in the negative group(P<0.05).There was no significant difference in DBIL between the two groups(P>0.05).Pearson test showed that TORCH-IgG antibody expression were positively correlated with TBIL,IBIL and DBIL levels(P<0.05).Spearman test showed that there was no correlation between the positive expression of TORCH-IgM antibody and pathological jaundice(P>0.05),and the positive expression of TORCHIgG antibody was positively correlated with pathological jaundice(P<0.05).Conclusion:The positive expression rate of TORCH-IgG antibody in jaundice newborns was higher than that in healthy newborns,and the expression of TORCH-IgG specific antibody was related to the occurrence and severity of jaundice.

关 键 词：黄疸新生儿 弓形虫 风疹病毒 巨细胞病毒 单纯疱疹病毒 

分 类 号：R722.17[医药卫生—儿科]