透明质酸钠改善尿路感染后腺性膀胱炎的临床研究  

Clinical Study of Sodium Hyaluronate in Improving Cystitis Glandularis after Urinary Tract Infection

作　　者：朱慧 周金才[2] Zhu Hui;Zhou Jincai(Jiangsu Medical Vocational College,Yancheng,224005;Jianhu Hospital Affiliated Nantong University,Yancheng,226021)

机构地区：[1]江苏医药职业学院,盐城224005 [2]南通大学附属建湖医院,盐城226021

出　　处：《基因组学与应用生物学》2019年第11期5209-5214,共6页Genomics and Applied Biology

摘　　要：为了探讨透明质酸钠治疗尿路感染后腺性膀胱炎的临床效果。本研究Nursing采用随机数字法将50例尿路感染后腺性膀胱炎患者随机分为两组(n=25),对照组受试者行常规疗法,观察组受试者采用膀胱内灌注透明质酸钠治疗,两个月后,比较两组受试者治疗效果。治疗后,两组受试者VAS、SAS评分均明显低于治疗前,且观察组明显低于对照组,两组间差异具有统计学意义(p<0.05)。治疗后,两组受试者ICPI、ICSI评分均较治疗前发生不同程度的降低,其中观察组受试者下降幅度明显大于对照组,两组间差异具有统计学意义(p<0.05)。研究结果表明,治疗后,对照组中痊愈、有效、无效的受试者分别为9例、11例、5例,观察组中分别为14例、9例、2例,观察组受试者治疗后临床有效率明显高于对照组(92.00%vs 80.00%),两组间差异具有统计学意义(p<0.05)。治疗后,两组受试者尿动力学指标均明显优于治疗前,其中观察组受试者FDV、MCC、Qmax、Pdet at Qmax、BC明显高于对照组,RUV明显低于对照组,两组间差异具有统计学意义(p<0.05)。治疗后6个月,观察组受试者复发率明显低于对照组(10.00%vs 20.00%),癌变率明显低于对照组(0.00%vs10.00%),且两组间差异具有统计学意义(p<0.05)。研究结论初步表明,膀胱内灌注透明质酸钠可有效改善尿路感染后腺性膀胱炎患者尿动力学指标,缓解患者焦虑状态,治疗效果明显优于常规疗法,且术后复发率、癌变率低,值得在临床中推广应用。To investigate the clinical effect of sodium hyaluronate in the treatment of cystitis glandularis after urinary tract infection,50 patients with cystitis glandularis after urinary tract infection were randomly divided into two groups(n=25)by random number method.The subjects in the control group were treated with conventional therapy.The subjects in the observation group were treated with sodium hyaluronate with intravesical instillation of sodium hyaluronate,and the treatment effect was compared in the two groups after two months.The results showed that after treatment,the scores of VAS and SAS in the two groups were significantly lower than those before treatment,and the observation group was significantly lower than that in the control group(p<0.05).After treatment,the scores of ICPI and ICSI in the two groups were reduced to different degrees compared with those before treatment,and the decrease in the observation group was significantly larger than that in the control group(p<0.05).After treatment,the patients in the control group were cured,effective and invalid in 9 cases,11 cases and 5 cases respectively.The observation group was 14 cases,9 cases and 2 cases respectively.The clinical effective rate of the observation group was significantly higher than that of the control group(92%vs 80%,p<0.05).After treatment,the urodynamic indexes of the two groups were obviously superior to those before the treatment,and the FDV,MCC,Qmax,Pdet at Qmax and BC in the observation group were significantly higher than those in the control group,and RUV was significantly lower than that of the control group(p<0.05).After 6 months of treatment,the recurrence rate of the observation group was significantly lower than that of the control group(10%vs 20%),and the canceration rate was significantly lower than that of the control group(0%vs 10%),and the difference was statistically significant(p<0.05).Preliminary findings indicated that intravesical infusion of sodium hyaluronate can effectively improve the urodynamic index of pat

关 键 词：尿路感染 腺性膀胱炎 透明质酸钠 临床效果 

分 类 号：R694.3[医药卫生—泌尿科学]