mPGES-2在非小细胞肺癌中的表达及临床意义  

Expression of mPGES-2 in non-small cell lung cancer and its clinical significance

作　　者：田蕾 吴丹妮 闫康乐 王文婷 范昕然 范毅敏[2] 李淑芬[3] 李婷[3] Tian Lei;Wu Danni;Yan Kangle(Chang zhi Medical College)

机构地区：[1]长治医学院,0460004 [2]长治医学院机能综合实验室 [3]长治医学院生理教研室

出　　处：《长治医学院学报》2019年第6期408-411,共4页Journal of Changzhi Medical College

基　　金：山西省高等学校大学生创新创业训练项目(2018398,2019399);山西省高等学校科技创新项目(2019L0662);山西省应用基础研究计划项目(201801D221444);山西省卫生健康委科研课题(2018126);长治医学院科技创新项目(CX201501)

摘　　要：目的:探讨微粒体前列腺素E合成酶2(m PGES-2)在肺癌中的表达及生物学意义,为研究肺癌的发生、发展及其可能的分子机制提供理论依据。方法:采用免疫组化PV两步法检测60例非小细胞肺癌(NSCLC)患者癌组织及20例肺癌患者癌旁组织中m PGES-2蛋白的表达水平。结果:NSCLC患者癌组织中m PGES-2的阳性率为66.67%,高于癌旁组织40.00%(P<0.05);m PGES-2的阳性表达与淋巴结转移、临床分期密切相关,与年龄、性别、病理分型、组织分化程度无相关性;有淋巴结转移患者阳性率为80.77%,高于无淋巴结转移患者55.88%(P<0.05);临床Ⅲ+Ⅳ期患者的阳性率为76.92%,高于临床Ⅰ+Ⅱ期47.62%(P<0.05)。结论:m PGES-2的高表达与NSCLC的发生发展及侵袭转移密切相关,m PGES-2可以作为评估肿瘤侵袭转移潜能及预后的一个重要指标。Objective:To investigate the expression and biological significance of microsomal prostaglandin E synthase type 2(m PGES-2)in lung cancer and to provide theoretical basis for the occurrence,development and possible molecular mechanisms of lung cancer.Methods:The two-step immunohistochemical PV method was used to detect the expression of m PGES-2 protein in cancer tissues of 60 patients with non-small cell lung cancer(NSCLC)and adjacent tissues of 20 lung cancer patients.Results:The positive rate of m PGES-2 in cancer tissues of NSCLC patients was 66.67%(40/60),which was significantly higher than that in adjacent tissues 40.00%(8/20)(P<0.05).The positive expression of m PGES-2 was closely related to lymph node metastasis and clinical stage,and had no significant correlation with age,gender,pathological type and tissue differentiation.The positive rate of lymph node metastasis was 80.77%(21/26),which was significantly higher than that of patients without lymph node metastasis55.88%(19/34).The positive rate of clinical stageⅢ+Ⅳpatients was 76.92%(30/39),which was significantly higher than clinicalⅠ+Ⅱstage 47.62%(10/21).Conclusion:The high expression of m PGES-2 is closely related to the development,invasion and metastasis of NSCLC.Therefore,m PGES-2 can be used as an important target to evaluate tumor invasion and metastasis potential and prognosis.

关 键 词：mPGES-2 非小细胞肺癌 免疫组织化学 

分 类 号：R181[医药卫生—流行病学]