参苏温肺汤加减对慢性鼻-鼻窦炎患者的临床疗效  

Clinical effects of Modified Sensu Wenfei Decoction on patients with chronic rhinosinusitis

作　　者：王俊杰[1] 蔡纪堂[1] 李静波[1] 王慧敏[1] 陈文明[1] WANG Jun⁃jie;CAI Ji⁃tang;LI Jing⁃bo;WANG Hui⁃min;CHEN Wen⁃ming(Department of Otorhinolaryngology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南省中医院耳鼻喉科

出　　处：《中成药》2020年第2期356-360,共5页Chinese Traditional Patent Medicine

基　　金：河南省高等学校重点科研项目(15A360005);河南省中医药科学研究专项课题(2014ZYO1002)

摘　　要：目的探讨参苏温肺汤加减对慢性鼻⁃鼻窦炎患者的临床疗效。方法180例患者随机分为参苏温肺汤加减组、泼尼松+丙酸氟替卡松组、联合用药组,每组60例,疗程60 d。检测临床疗效、症状评分(VAS、Lund⁃Kennedy、Lund⁃Mackay、SNOT⁃20)、肺通气功能指标(FEV1、FVC、FEV1/FVC、PEF)、血清和鼻腔分泌物炎性因子(TNF⁃α、IFN⁃γ、IL⁃1β、IL⁃17)、不良反应发生率变化。结果联合用药组总有效率较参苏温肺汤加减组、泼尼松+丙酸氟替卡松组升高(P<0.05)。治疗后,联合用药组症状评分、肺通气功能指标、血清及鼻腔分泌物炎性因子改善程度较其他2组更明显(P<0.05)。各组不良反应发生率依次为参苏温肺汤加减组高于联合用药组高于泼尼松+丙酸氟替卡松组(P<0.05)。结论参苏温肺汤加减对慢性鼻⁃鼻窦炎患者临床疗效良好,安全性高,联合泼尼松+丙酸氟替卡松时具有减毒增效作用。AIM To explore the clinical effects of Modified Sensu Wenfei Decoction on patients with chronic rhinosinusitis.METHODS One hundred and eighty patients were randomly assigned into Modified Sensu Wenfei Decoction group(60 cases),prednisone+fluticasone propionate group(60 cases)and combined medication group(60 cases),all the three groups were given 60⁃day administation.The changes in clinical efficacy,symptom scores(VAS,Lund⁃Kennedy,Lund⁃Mackay,SNOT⁃20),pulmonary ventilation function indices(FEV1,FVC,FEV1/FVC,PEF),serum and nasal cavity secretion inflammatory factors(TNF⁃α,IFN⁃γ,IL⁃1β,IL⁃17)and occur⁃rence of adverse reactions were detected.RESULTS The combined medication group demonstrated higher total effective rate than the Modified Sensu Wenfei Decoction group and prednisone+fluticasone propionate group(P<0.05).After the treatment,the combined medication group displayed better improvement degrees in symptom scores,pulmonary ventilation function indices and serum and nasal cavity secretion inflammatory factors than the other two groups(P<0.05).The occurrence of adverse reactions in various groups was in sequence of the Modified Sensu Wenfei Decoction group higher than the combined medication group higher than the prednisone+fluticasone propionate group(P<0.05).CONCLUSION For the patients with chronic rhinosinusitis,Modified Sensu Wenfei Decoction has good clinical efficacy and high safety,which exhibits toxicity reducing and efficacy enhancing effects when combined with prednisone+fluticasone propionate.

关 键 词：参苏温肺汤加减 泼尼松 丙酸氟替卡松 慢性鼻⁃鼻窦炎 

分 类 号：R287[医药卫生—中药学]