荷叶调脂疏肝汤联合二甲双胍对糖耐量异常合并非酒精性脂肪肝患者的临床疗效  

Clinical effects of Heye Tiaozhi Shugan Decoction combined with metformin on patients with impaired glucose tolerance and non-alcohol fatty liver disease

作　　者：王文川 李鑫 殷建敏 岳亚光[1] 郭恺 李冠阳 WANG Wen⁃chuan;LI Xin;YIN Jian⁃min;YUE Ya⁃guang;GUO Kai;LI Guan⁃yang(Department of Hepatology,Xingtai Municipal People’s Hospital,Xingtai 054031,China)

机构地区：[1]邢台市人民医院肝病科

出　　处：《中成药》2020年第2期360-364,共5页Chinese Traditional Patent Medicine

基　　金：河北省中医药管理局科研计划项目(2019511)

摘　　要：目的考察荷叶调脂疏肝汤联合二甲双胍对糖耐量异常合并非酒精性脂肪肝患者的临床疗效。方法116例患者随机分为对照组和观察组,每组58例,对照组给予二甲双胍,观察组在对照组基础上加用荷叶调脂疏肝汤,疗程3个月。检测临床疗效、肝功能指标[谷草转氨酶(GOT)、谷丙转氨酶(GPT)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL⁃C)]、血糖指标[空腹血糖(FBG)、餐后2 h血糖(2 h PG)]、胰岛功能指标[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA⁃IR)]、瘦素(LEP)、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组肝功能指标、血脂指标、血糖指标、胰岛功能指标、LEP降低(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论荷叶调脂疏肝汤联合二甲双胍可有效调节糖耐量异常合并非酒精性脂肪肝患者机体糖脂代谢,抑制体内LEP表达,改善胰岛素抵抗及肝功能,安全性高。AIM To investigate the clinical effects of Heye Tiaozhi Shugan Decoction combined with metformin on patients with impaired glucose tolerance and non⁃alcohol fatty liver disease.METHODS One hundred and sixteen patients were randomly assigned into control group(58 cases)for 3⁃month administration of metformin,and observation group(58 cases)for 3⁃month administration of both Heye Tiaozhi Shugan Decoction and metformin.The changes in clinical efficacy,liver function indices[glutamic oxalacetic transaminase(GOT),glutamic⁃pyruvic transaminase(GPT)],blood lipid indices[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL⁃C)],blood glucose indices[fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG)],islet function indices[fasting insulin(FINS),insulin resistance index(HOMA⁃IR)],leptin(LEP)and occurrence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased liver func⁃tion indices,blood lipid indices,blood glucose indices,islet function indices and LEP(P<0.05),especially for the observation group(P<0.05).No obvious difference in the occurrence of adverse reactions were found between the two groups(P>0.05).CONCLUSION For the patients with impaired glucose tolerance and non⁃alcohol fatty liver disease,Heye Tiaozhi Shugan Decoction combined with metformin can effectively regulate body glucolipid metabolism,inhibit the in vivo expression of LEP,and improve insulin resistance and liver functions,exhibiting high safety.

关 键 词：荷叶调脂疏肝汤 二甲双胍 糖耐量异常 非酒精性脂肪肝 

分 类 号：R287[医药卫生—中药学]