浙江省首例新型冠状病毒肺炎报告病例流行病学调查  

Epidemiological investigation of the first reported case of coronavirus disease 2019 (COVID-19) in Zhejiang Province

作　　者：凌锋[1] 刘社兰[1] 倪朝荣[2] 潘金仁[1] 刘营 陈恩富[1] 余向华[2] LING Feng;LIU Shelan;NI Chaorong;PAN Jinren;LIU Ying;CHEN Enfu;YU Xianghua(Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China)

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051 [2]温州市疾病预防控制中心

出　　处：《预防医学》2020年第2期109-112,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：浙江大学新型冠状病毒肺炎(COVID-19)应急科研专项

摘　　要：目的对浙江省首例新型冠状病毒肺炎(COVID-19)报告病例开展流行病学调查,为COVID-19疫情防控提供参考。方法按照国家卫生健康委员会发布的《新型冠状病毒感染的肺炎诊疗方案(试行)》和《新型冠状病毒感染的肺炎疫情防控方案(试行)》,采用现场流行病学调查方法对温州市2020年1月15日报告的1例由武汉市返回的发热病例进行个案调查;采集痰液和咽拭子标本,采用实时荧光RT-PCR法检测严重急性呼吸道综合征冠状病毒2型(SARS-CoV-2)核酸;追踪排查密切接触者,并及时落实相关防控措施。结果该病例长期居住武汉市,2020年1月4日无明显诱因自感畏寒不适,并与其妻驾车回浙江省温州市;1月5日出现发热(最高体温39℃)、咳嗽、咳痰等症状;1月9日胸部CT显示两下肺见斑片状高密度影,边缘模糊;1月16日采集咽拭子和痰液标本,送浙江省疾病预防控制中心检测SARS-CoV-2核酸,1月17日报告SARS-CoV-2核酸阳性,1月20日经中国疾病预防控制中心复核并确认阳性。发病前2周病例主要在武汉市某老旧居民小区入户做电梯加装的说服工作,自述无相关病例接触史,无农贸市场活动史,无(病死)禽接触史,也无禽肉及制品食用史。共追踪到26名密切接触者并进行隔离医学观察,其间3人出现发热或呼吸道症状,经检测均排除SARS-CoV-2感染。1月16日下午,浙江省、温州市卫生健康系统迅速启动应急预案,落实现症病例隔离治疗、密切接触者筛查隔离和加强居民健康教育等一系列防控措施。结论根据温州市该例病例的流行病学史、临床表现和实验室检测结果,判定为浙江省首例新型冠状病毒肺炎报告病例。Objective To conduct an epidemiological investigation on the first reported case of coronavirus disease 2019(COVID-19)in Zhejiang Province,so as to provide reference for prevention and control of the disease.Methods According to the COVID-19 Diagnosis and Treatment Program(Trial)and the COVID-19 Prevention and Control Program(Trial)issued by National Health Commission of China,a field investigation was employed on a case of fever from Wuhan reported by Wenzhou in January 15,2020;the real-time reverse transcription polymerase chain reaction(RT-PCR)assay was performed to detect the nucleic acid of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from the sputum specimens or throat swabs of the case;the close contacts of the case were tracked down;relevant prevention and control measures were implemented.Results The case had lived in Wuhan for long.On January 4 of 2020,he felt cold and uncomfortable without obvious inducement,and drove back to Wenzhou with his wife.He had fever(up to 39℃),cough and expectoration on the next day.On January 9,the chest computed tomographic(CT)scan showed bilateral high-density patchy shadowing with blurred edges.On January 16,his throat swab and sputum samples were collected and sent to Zhejiang Provincial Center for Disease Control and Prevention(CDC)for detection of SARS-CoV-2.The result turned out to be positive on January 17,then was rechecked and confirmed by Chinese CDC on January 20.Two weeks before the onset of the disease,the patient was engaged in the door-to-door persuasion of installing elevators in an old residential area of Wuhan,and he denied any connection with other COVID-19 cases,markets,(sick or dead)poultry or poultry products.Totally 26 close contacts were identified and kept in quarantine.During this period,three of them developed fever or respiratory symptoms,but were excluded from COVID-19.On the afternoon of January 16,the health system of Zhejiang Province and Wenzhou City launched an emergency plan and implemented a series of prevention and contr

关 键 词：新型冠状病毒肺炎 严重急性呼吸道综合征冠状病毒2型 流行病学调查 

分 类 号：R181.3[医药卫生—流行病学]