针灸联合硝苯地平控释片对原发性高血压病人血浆TXA2/PGI2平衡及血液流变学的影响  

Influences of Acupuncture and Moxibustion Plus Nifedipine Controlled Release Tablets on Plasma TXA2/PGI2 Balance and Hemorheology in Patients with Essential Hypertension

作　　者：汤峥丽[1] 汤峥冬[1] 童秋瑜[1] 王芳[1] 阴霄飞 TANG Zhengli;TANG Zhengdong;TONG Qiuyu;WANG Fang;YIN Xiaofei(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院

出　　处：《中西医结合心脑血管病杂志》2019年第24期3890-3893,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金面上项目(No.81473759)

摘　　要：目的探讨针灸联合硝苯地平控释片对原发性高血压病人血浆血栓素A 2(A 2,TXA 2)、前列腺素I 2(PGI 2)平衡以及对血液流变学的影响。方法选择2016年4月-2018年4月于上海中医药大学附属曙光医院接受诊治的原发性高血压病人108例,依据随机数字表法进行分组,每组54例。对照组病人接受硝苯地平控释片治疗,研究组接受针灸与硝苯地平控释片联合治疗。治疗5周后评价两组临床疗效,测定收缩压、舒张压,采用血栓素B 2(TXB 2)与6酮-前列腺素F1α(6-Keto-PGF1α)以及TXA 2/6-Keto-PGF1α比值观察血浆TXA 2/PGI 2平衡情况,观察血液流变学指标,并统计复发率。结果研究组总有效率明显高于对照组(P<0.05);治疗后两组收缩压与舒张压水平明显降低(P<0.05),且组间比较差异有统计学意义(P<0.05);治疗后两组TXB 2及二者比值均明显降低(P<0.05),治疗后两组6-Keto-PGF1α明显升高(P<0.05),且组间比较差异有统计学意义(P<0.05);治疗后两组血液流变学各项观察指标均明显降低(P<0.05),且组间比较差异有统计学意义(P<0.05);对照组复发率(11.11%)与研究组(0)比较,差异有统计学意义(P<0.05)。结论针灸联合硝苯地平控释片可明显提高原发性高血压病人临床疗效,良好控制收缩压与舒张压,维持血浆TXA 2与PGI 2平衡,在改善血液流变学相关指标以及复发率等方面亦具有确切效果。Objective To investigate the influences of acupuncture and moxibustion plus nifedipine controlled release tablets on plasma thromboxane A 2(TXA 2),prostaglandin I 2(PGI 2)balance,and hemorheology in patients with essential hypertension(EH).Methods One hundred and eight patients with EH in our hospital from April 2016 to April 2018 were divided into two groups according to random number table method:the control group(n=54)treated with nifedipine controlled release tablets,and the treatment group(n=54)treated with acupuncture and moxibustion plus nifedipine controlled release tablets for 5 weeks.After 5 weeks of treatment,the clinical efficacy of two groups was evaluated.The systolic pressure and diastolic pressure were measured.The thromboxane B 2(TXB 2)and 6-keto-prostaglandin F1 alpha(6-Keto-PGF1α)and their ratios were measured,and the plasma TXA 2/PGI 2 balance was observed.The hemorheological indexes and the recurrence rate were observed.Results The total effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,systolic pressure and diastolic pressure levels were significantly lower in two groups(P<0.05),and there was a significant difference between two groups(P<0.05).After treatment,TXB 2 and the ratio of TXB 2 to 6-Keto-PGF1αwere significantly decreased in two groups(P<0.05),and 6-Keto-PGF1αwas significantly increased in two groups(P<0.05),and the difference between two groups was statistically significant(P<0.05).After treatment,the hemorheological indexes of two groups were significantly decreased(P<0.05),and the difference between two groups was statistically significant(P<0.05).The recurrence rate in the study group was lower than that in the control group,and the difference was statistically significant(0%vs 11.11%,P<0.05).Conclusion Acupuncture and moxibustion plus nifedipine controlled release tablets can significantly improve the clinical efficacy of EH,control systolic pressure and diastolic pressure,maintain the balance of plasma TXA 2 an

关 键 词：原发性高血压 针灸 硝苯地平控释片 血栓素A 2 前列腺素I 2 血液流变学 

分 类 号：R544.1[医药卫生—心血管疾病] R255.3[医药卫生—内科学]