扶阳益气活血中药对脑血管支架植入术后血管内皮功能、C反应蛋白、氧化应激指标、中医证候积分及脑血管事件的影响  

The Influence of Fuyang Yiqi Huoxue Medicine on Vascular Endothelial Function,C-Reactive Protein,Oxidative Stress Index,TCM Syndromes,and Cerebral Vascular Events after Cerebral Stent Implantation

作　　者：许瑞卿[1] 胡杰 吕祥龙[1] XU Ruiqing;HU Jie;LYU Xianglong(Chuzhou Traditional Chinese and Western Medicine Hospital,Chuzhou 239000,Anhui,China)

机构地区：[1]滁州市中西医结合医院

出　　处：《中西医结合心脑血管病杂志》2020年第1期156-160,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨扶阳益气活血中药对脑血管支架植入术后不同时期血管内皮功能、C反应蛋白、氧化应激指标、中医证候积分及脑血管事件发生率的影响。方法将80例行脑血管支架植入术病人分为中药组、常规治疗组,每组40例。分别检测术前、术后1 d、治疗后2个月、治疗后6个月血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)]、C反应蛋白、氧化应激指标[血清超氧化物歧化酶(SOD)、丙二醛(MDA)]水平,并观察两组治疗前后中医证候积分(气虚证积分、血瘀证积分)、美国国立卫生研究院卒中量表(NIHSS)评分变化及脑血管事件的发生情况。结果两组术后1 d ET-1、SOD、C-反应蛋白、气虚证积分、血瘀证积分升高,NO、MDA、NIHSS评分下降,但与术前比较差异无统计学意义(P>0.05);治疗2个月后,两组ET-1、MDA、C-反应蛋白、NIHSS水平较术后1 d明显降低(P<0.05),NO、SOD较术后1 d明显升高(P<0.05),且中药组优于常规治疗组(P<0.05);常规治疗组中医证候积分较术后1 d无明显变化(P>0.05),但中药组中医证候积分较术后1 d下降(P<0.05),且中药组与常规治疗组比较差异有统计学意义(P<0.05);两组治疗6个月后,ET-1、MDA、C-反应蛋白、NIHSS评分水平较治疗2个月时明显下降(P<0.05),NO、SOD水平较治疗2个月时明显升高(P<0.05),且中药组与常规治疗组比较差异有统计学意义(P<0.01),常规治疗组中医证候积分较2个月时无明显变化(P>0.05),但中药组中医证候积分较2个月时明显下降(P<0.05),且中药组与常规治疗组比较差异有统计学意义(P<0.05)。治疗6个月后中药组再狭窄发生率12.5%(5/40),脑缺血事件发生率5.0%(2/40),常规治疗组再狭窄发生率32.5%(13/40),脑缺血事件发生率15.0%(6/40),两组脑缺血事件及再狭窄发生率比较差异有统计学意义(P<0.05)。结论扶阳益气活血中药能够保护脑血管支架植入术后血管内皮功能,降低C反应蛋白,改善氧�Objective To explore the influence of Fuyang Yiqi Huoxue traditional Chinese medicine on vascular endothelial function,C-reactive protein,oxidative stress index,TCM syndromes,and cerebral vascular events in different periods after cerebral stent implanta-tion.Methods Eighty cerebrovascular patients with cerebral stent implantation were divided into Chinese medicine group(n=40)and control group(n=40).At 1 day,2 months,and 6 months postoperation,endothelial function indicators[nitric oxide(NO),endothelin-1(ET-1),C-reactive protein,and oxidative stress indicator[serum superoxide dismutase(SOD),malondialdehyde(MDA)]were meas-ured,and the changes of TCM syndrome score(deficiency syndrome score,score of blood stasis syndrome),national institutes of health stroke scale(NIHSS)score and cerebrovascular events were observed before and after treatment.Results The scores of ET-1,SOD,C-reactive protein,qi deficiency syndrome score and blood stasis syndrome score were increased after cerebral vascular inter-vention,while the scores of NO,MDA,and NIHSS were decreased,but there were no significant difference compared with those before treatment(P>0.05).After 2 months of conventional treatment and traditional Chinese medicine treatment,ET-1,MDA,C-reactive pro-tein,and NIHSS levels were all significantly lower than 1 d postoperative(P<0.05),NO and SOD increased significantly(P<0.05),however,the TCM syndrome score of the TCM group decreased compared with that at the day after surgery(P<0.05),and that be-tween the TCM group and the conventional group was statistically significant difference(P<0.05).After six months of treatment,MDA,ET-1,C-reactive protein,NIHSS levels in two groups were all significantly lower than those of 2 months postoperation(P<0.05),NO and SOD increased significantly(P<0.05),and there was a statistically significant difference between the traditional Chinese medi-cine group and the conventional group(P<0.01).The TCM syndrome score of the conventional treatment group showed no signifi-cant change compared with t

关 键 词：脑血管支架植入术 扶阳益气活血中药 血管内皮功能 C反应蛋白 氧化应激指标 血瘀证积分 气虚证积分 预后 

分 类 号：R318[医药卫生—生物医学工程] R289.5[医药卫生—基础医学]