槐定碱微球制备工艺研究  

Study on preparation technology of sophoridine microspheres

作　　者：胡扬[1] 薛昊 王金宏[1] 王昊 徐蓓蕾[1] 孙丽鹏 杨波[1] HU Yang;XUE Hao;WANG Jin-hong;WANG Hao;XU Bei-lei;SUN Li-peng;YANG Bo(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院

出　　处：《哈尔滨商业大学学报（自然科学版）》2020年第1期8-12,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：哈尔滨市应用技术研究与开发项目(2016RAQXJ009)

摘　　要：研究槐定碱微球的制备工艺.以乳化交联法制备槐定碱微球,结合单因素实验结果选择影响显著的因素壳聚糖用量、交联时间、乳化剂用量为三因素,以微球的包封率、载药量、粒径作为考察指标,进行正交实验.确定槐定碱微球制备工艺为交联时间3.5 h,乳化剂用量0.63 g,壳聚糖用量0.05g,槐定碱用量0.04 g,温度40℃,油水比3∶1.槐定碱微球的平均包封率为(35.57±0.76)%,平均载药量为(5.52±0.17)%,平均粒径为(8.96±0.21)μm,方法重现性良好.In this paper,the preparation technology of sophoridine microspheres was studied,cross-linking was established as the preparation method of sophoridine microspheres. Refer to the results of single factor and orthogonal tests,chitosan dosage,crosslinking time,emulsifier dosage were selected as influence factors. Entrapment rate,drug loading,particle size were selected as index. The obtained microspheres was well-distributed and table.Crosslinking time was 3. 5 h,emulsifier dosage 0. 63 g,chitosan dosage 0. 05 g,sophoridine dosage 0. 04 g,the preparation temperature 40 ℃,oil-water ratio 3: 1. Entrapment rate was( 35. 57 ± 0. 76) %. Drug loading was( 5. 52 ± 0. 17) %. Particle size was( 8. 96 ± 0.21) μm. the preparation method was reproducible.

关 键 词：槐定碱 微球 乳化交联法 单因素实验 制备工艺 正交实验 

分 类 号：R944.9[医药卫生—药剂学]