CMC/阳离子β-CD静电自组装水凝胶的制备及其缓释性能  

Preparation and Sustained-release Performance of Electrostatic Self-assembled Hydrogels with CMC/Cationic β-CD

作　　者：刘瑜[1] 徐力 贾盼 贾旺强 郑进智 刘泽华[1] LIU Yu;XU Li;JIA Pan;JIA Wangqiang;ZHENG Jinzhi;LIU Zehua(Tianjin Key Laboratory of Pulp and Paper,College of Light Industry Science and Engineering,Tianjin University of Science&Technology,Tianjin 300457,China)

机构地区：[1]天津市制浆造纸重点实验室天津科技大学轻工科学与工程学院

出　　处：《天津科技大学学报》2020年第1期44-50,共7页Journal of Tianjin University of Science & Technology

基　　金：国家级大学生创新创业训练计划资助项目(201710057090)

摘　　要：利用静电自组装原理将具有疏水性空腔的阳离子β–环糊精引入羧甲基纤维素(CMC)网络体系中,制备一种新型的pH敏感性水凝胶用于疏水性药物的控释.当组装时间为9 min以上,阳离子β–环糊精取代度为0.68且其溶液的质量分数为30%时,凝胶中β–环糊精含量可达到实验最大值.因为交联层厚度及CMC链之间的静电斥力发生变化,凝胶溶胀率随着pH的增大开始减小,同时凝胶结构随pH增大而变得更加致密.以疏水性氯霉素为模型药物,其最大载药量为215.33 mg/g,用Korsmeyer-Peppas模型对释药过程的动力学数据进行拟合,在pH 4和pH 6的缓冲液中满足Quasi-Fickian扩散模型,而在pH 7的缓冲液中符合Non-Fickian扩散机理.A novel pH responsive hydrogel was prepared for the controlled release of hydrophobic drugs and cationicβ-cyclodextrin by introducing hydrophobic cavity into the carboxymethyl cellulose(CMC)network,based on electrostatic selfassembly theory.When the assembly time was more than 9 min,the degree of substitution of cationicβ-cyclodextrin 0.68 and the solution concentration 30%,the content ofβ-cyclodextrin in the hydrogel can reach the experimental maximum.Due to the changes of thickness of the cross-linked layer and the electrostatic repulsion between the CMC chains,the equilibrium swelling rate decreased with the increase of buffer pH,and the gel structure became denser as the pH increased.The loading of drug that depended on the content ofβ-cyclodextrin in the hydrogel could reach 215.33 mg/g,when chloramphenicol was chosen as a model hydrophobic drug.The kinetics data of the drug release were analyzed according to Korsmeyer-Peppas model.The hydrogel showed Quasi-Fickian release behavior in the buffers at pH 4 and pH 6,while the Non-Fickian diffusion mechanism was observed at pH 7.

关 键 词：静电自组装 水凝胶 羧甲基纤维素 β–环糊精 控释 

分 类 号：O636.1[理学—高分子化学]