群体感应与群体淬灭控制病原菌的研究进展  

Progress in quorum sensing and quorum quenching control animal pathogens

作　　者：李胜利 孙海洲[2] 金鹿[2] 桑丹[2] 张崇志[2] 张春华[2] 郝永清[1] LI Sheng-li;SUN Hai-zhou;JIN Lu;SANG Dan;ZHANG Chong-zhi;ZHANG Chun-hua;HAO Yong-qing(Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease of the Ministry of Agriculture/College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;Inner Mongolia Key Laboratory of Herbivores Nutrition,Institute of Animal Nutrition and Feed,Inner Mongolia Academy of Agricultural&Animal Sciences,Hohhot 010031,China)

机构地区：[1]内蒙古农业大学兽医学院农业部动物疾病临床诊疗技术重点实验室,内蒙古呼和浩特010018 [2]内蒙古农牧业科学院动物营养与饲料研究所内蒙古自治区草食动物营养科学重点实验室,内蒙古呼和浩特010031

出　　处：《中国兽医科学》2020年第1期72-83,共12页Chinese Veterinary Science

基　　金：国家现代农业产业技术体系建设专项资金(CARS-39-11);内蒙古自然科学基金面上(联合)基金(2017MS(LH)0311);内蒙古自治区重大基础研究开放课题“草食家畜瘤胃可发酵碳水化合物调控技术研究”联合资助

摘　　要：当前,随着病原菌抗生素耐药性不断增强,开发防控病原菌的新方法是全球面临的主要挑战之一。许多重要的动物病原菌通过"群体感应"作用来调控病原菌毒力。因此,对病原菌的群体感应进行干扰即"群体淬灭",从而开发控制疾病的新疗法已经成为新兴的研究热点。本文综述了病原菌群体感应,群体感应对病原菌致病性和肠道健康影响,以及利用群体淬灭开发药物等方面最近进展。The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would be one of the major challenges we will face.Microbial cells do not live in isolation in their environment,but rather they communicate with each other using chemical signals.Many important animal pathogens regulate virulence by quorum sensing,bacterial cell-to-cell communication with small signal molecules.Consequently,a significant research effort is being undertaken to identify and use quorum sensing inhibitors and quorum quenching enzymes in order to control diseases caused by these pathogens.In this review,an overview of our current knowledge of quorum-sensing systems of Gram-negative model pathogens is presented as well as the link with virulence of these pathogens,and recent advances and challenges in the development of quorum-sensing-interfering therapies are discussed.

关 键 词：病原菌 群体感应 群体淬灭 群体感应抑制剂 

分 类 号：S855.1[农业科学—临床兽医学]