长链非编码RNA中INK4基因座中反义非编码RNA在糖尿病视网膜病变中的研究现状  

Research status of antisense non-coding RNA in INK4 locus in long-chain non-coding RNA in diabetic retinopathy

作　　者：陈舒泽 于正桐 王梓鸿 梁晓茜 钟惠敏 符敏[2] Chen Shuze;Yu Zhengtong;Wang Zihong;Liang Xiaoqian;Zhong Huimin;Fu Min(The Second Medical College of Southern Medical University,Guangzhou 510515,China;Department of Ophthalmology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学第二临床医学院,广州510515 [2]南方医科大学珠江医院眼科,510280

出　　处：《中华眼底病杂志》2020年第1期78-81,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：2018年度大学生创新创业训练计划。

摘　　要：糖尿病视网膜病变(DR)发病机制复杂。长链非编码RNA(lncRNA)中INK4基因座中反义非编码RNA(ANRIL)与细胞增生、分化及个体发育过程密切相关,在视网膜血管内皮细胞的异常增生中起重要作用,是DR发病机制研究中的新领域。现有研究发现,ANRIL可能通过核因子-κB、ROS/聚腺苷二磷酸核糖聚合酶信号通路以及与p300、miR-200b、EZH2协同调节VEGF在DR中的表达和功能,发挥其在DR发生发展中的作用。特异性阻断ANRIL及其相关通路,可能成为未来DR临床治疗中的新靶点。The pathogenesis of diabetic retinopathy(DR)is complex.Antisense non-coding RNA(ANRIL)in the INK4 locus in long-chain non-coding RNA(lncRNA)is closely related to cell proliferation,differentiation,and individual development.It plays an important role in the dysplasia of retinal vascular endothelial cells and is a new field in the study of the pathogenesis of DR.According to the researches at present,ANRIL may plays its role in the occurrence and development of DR through the signal pathway of nuclear factor-κB and ROS/polyadenylation diphosphate ribose polymerase,and interact with p300,miR-200b,and EZH2 to regulating the expression and function of VEGF.Specific blocking ANRIL and its related pathways may become a new target in the treatment of DR.

关 键 词：糖尿病视网膜病变 综述 长链非编码RNA INK4基因座中反义非编码RNA 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]