A novel pig model capturing clinical symptoms of harlequin ichthyosis  

作　　者：Kiho Lee 

机构地区：[1]Department of Animal and Poultry Sciences,Virginia Tech,Blacksburg,VA 24061,USA

出　　处：《Journal of Molecular Cell Biology》2019年第12期1027-1028,共2页分子细胞生物学报（英文版）

摘　　要：The application of proper animal models is essential for developing effective treatments in biomedicine. Due to practicality, rodent models have been dominantly used as a model to identify potential treatments for patients. However, differences in physiology and anatomy between rodents and humans have been an obstacle when translating the data generated from rodents to clinics. Large animal models such as pigs can recapitulate symptoms of human diseases, making pigs an ideal model for preclinical assessment of new treatments (Prather et al., 2013). For instance, symptoms of primary immunodeficiency are more accurately represented in pigs compared to mice (Suzuki et al., 2012), demonstrating their suitability as an animal model in biomedicine. Unfortunately, the number of available pig models is low, in part, because of challenges in establishing pig models through current genetic engineering technology.

关 键 词：ANATOMY establishing SUITABILITY 

分 类 号：S82[农业科学—畜牧学]