毛细管电泳在手性化合物分离分析中的研究进展  

Recent advances of separation and analysis of chiral compounds by capillary electrophoresis

作　　者：刘明霞 李向军 白玉[1] 刘虎威[1] LIU Mingxia;LI Xiangjun;BAI Yu;LIU Huwei(Beijing National Laboratory for Molecular Sciences,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;School of Chemical Sciences,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]北京分子科学国家实验室,北京大学化学与分子工程学院,北京100871 [2]中国科学院大学化学科学学院,北京100049

出　　处：《色谱》2020年第3期317-323,共7页Chinese Journal of Chromatography

基　　金：国家自然科学基金项目(21527809,21775008)~~

摘　　要：手性化合物的对映异构体往往表现出不同的生理活性,因此建立手性化合物的有效分离分析方法具有重要意义。毛细管电泳(CE)是一种分离效率高、分析速度快、样品用量少、分离模式灵活多样的分离分析方法,在手性化合物的分离和检测领域应用广泛。该文主要综述了2017~2019年CE在手性分离分析方面的最新进展,并对其未来的发展趋势进行了展望。As the enantiomers of chiral compounds often exhibit different physiological activities,the establishment of effective separation and analytical methods for chiral compounds is of great significance.As a widely used chiral separation and detection technique,capillary electrophoresis(CE)offers the advantages of high separation efficiency,high speed,small sample consumption and flexible separation mode.In this review,research progresses in chiral separation by CE for the period 2017 to 2019 are summarized,and future developments are prospected.

关 键 词：毛细管电泳 手性分离 综述 

分 类 号：O658[理学—分析化学]