糖尿病老年患者膀胱纤维化和氧化应激状态的关联研究  

Association between bladder fibrosis and oxidative stress in elderly diabetic patients

作　　者：杨必林 邱志勇 林珊 蓝燕思 Yang Bilin;Qiu Zhiyong;Lin Shan;Lan Yansi(Department of Urology,the People's Hospital of Huidong County,Huizhou 516300,China)

机构地区：[1]广东省惠东县人民医院泌尿外科,516300

出　　处：《国际泌尿系统杂志》2020年第1期17-21,共5页International Journal of Urology and Nephrology

摘　　要：目的探讨糖尿病老年患者膀胱纤维化和氧化应激状态的关联性。方法本研究选取2017年6月至2017年12月期间本院收治的30例老年膀胱纤维化相关糖尿病患者为研究对象(观察组,30例),以同期入院体检的健康人群(对照1组,30例)以及本院同期收治的非膀胱纤维化老年糖尿病(对照2组,30例)作为对照。检测受试者空腹血糖、餐后2 h血糖和糖化血红蛋白。比较三组受试者膀胱障碍发生情况、尿动力学指标以及氧化应激指标。采用logistic多因素回归分析血清氧化应激指标表达水平与糖尿病老年患者膀胱纤维化的相关性。结果对照2组、观察组受试者空腹血糖、餐后2 h血糖和糖化血红蛋白均高于对照1组,差异有统计学意义(P<0.05);对照2组与观察组受试者间空腹血糖、餐后2 h血糖和糖化血红蛋白差异无统计学意义(P>0.05)。观察组受试者不稳定膀胱、低顺应性膀胱、膀胱感觉减退发生率高于对照1组、对照2组(P<0.05)。观察组受试者最大尿流率、逼尿肌收缩压力低于对照1组、对照2组,残余尿量高于对照1组、对照2组(P<0.05)。观察组受试者最大膀胱容量、初始尿意膀胱容量、平均膀胱容量均高于对照1组、对照2组(P<0.05)。观察组受试者血清过氧化氢(CAT)、血清超氧化物歧化酶(SOD)表达水平低于对照1组、对照2组(P<0.05),血清丙二醛(MDA)表达水平高于对照1组、对照2组(P<0.05);对照2组受试者CAT、SOD表达水平低于对照1组(P<0.05),MDA表达水平高于对照2组(P<0.05)。Logistic多因素回归分析结果显示,CAT、SOD、MDA表达水平与膀胱纤维化相关老年糖尿病发病显著相关(P<0.05)。结论膀胱纤维化相关老年糖尿病患者膀胱功能存在一定障碍,尿动力学指标异常,氧化应激指标表达水平异常。Objective To investigate the association between bladder fibrosis and oxidative stress in elderly diabetic patients.Methods In this study,30 elderly patients with bladder fibrosis related diabetes treated in our hospital from June 2017 to December 2017 were selected as the research object(observation group,n=30),and the healthy population(control group 1,n=30)and non bladder fibrotic senile diabetes mellitus(control group 2,n=30)in our hospital during the same period were used as control.Fasting blood glucose,postprandial 2H blood glucose and glycosylated hemoglobin were detected.Bladder dysfunction,urodynamic indexes and oxidative stress indexes were compared between the three groups.Multivariate logistic regression analysis was used to analyze the correlation between serum oxidative stress index and bladder fibrosis in elderly diabetic patients.Results The fasting blood glucose,postprandial blood glucose and glycosylated hemoglobin of control group 2 and observation group were higher than those of control group 1(P<0.05),and there were no significant differences in fasting blood glucose,postprandial blood glucose and glycosylated hemoglobin between control group 2 and observation group(P>0.05).The incidence of unstable bladder,low compliance bladder and bladder depression in the observation group was higher than that in the control group 1 and the control group 2(P<0.05).The maximal urine flow rate and detrusor contraction pressure in the observation group were lower than those in the control group 1 and the control group 2,and the residual urine volume was higher than that in the control group 1 and the control 2 group(P<0.05).The maximum bladder volume,initial urinary bladder capacity and average bladder capacity in the observation group were higher than those in the control group 1 and the control group 2(P<0.05).The expression level of CAT and SOD in the observation group was lower than that of the control group 1 and the control 2 groups(P<0.05).The expression level of MDA was higher than that of the contr

关 键 词：糖尿病 老年人 膀胱 纤维化 氧化性应激 

分 类 号：R587.2[医药卫生—内分泌]