COPD患者HRCT表型与临床特征的关系  

Relationship Between HRCT Phenotype and Clinical Features in Patients with COPD

作　　者：卜容蓉 杨才勇[2] 李丹 朱凤[2] 陈娜[3] BU Rong-rong;YANG Cai-yong;LI Dan(Department of Respiratory,Ankang Central Hospital,Ankang 725000,Shaanxi Province,China;不详)

机构地区：[1]陕西省安康市中心医院呼吸科,陕西安康725000 [2]陕西省安康市中心医院感染科,陕西安康725000 [3]西安交通大学第一附属医院感染科,陕西西安710061

出　　处：《中国CT和MRI杂志》2019年第12期68-70,90,共4页Chinese Journal of CT and MRI

基　　金：陕西省科技厅社会发展科技攻关项目(编号:2016SF-248)

摘　　要：目的探究慢性阻塞性肺疾病(COPD)患者高分辨率CT(HRCT)表型与临床特征之间的关系。方法选择2014年2月至2018年3月我院呼吸科收治的95例稳定期COPD患者纳入研究,所有患者均行HRCT检查、病史采集及肺功能检查,根据HRCT检查结果进行分型,比较不同分型COPD患者各临床指标差异。结果入组患者中A型37例,E型29例,M型29例,E型及M型患者低密度衰减区域(LAA)评分比较差异无统计学意义(P>0.05);A型患者LAA评分显著低于其他两组(P<0.05);A型患者呼吸困难评分、第1秒用力肺活量(FEV1)及第1秒用力肺活量占用力肺活量的百分比(FEV1/FVC)显著低于E、M型(P<0.05);M型患者咯痰评分显著高于A、E型(P<0.05)。结论HRCT表型与COPD患者临床症状及肺功能指标相关,可作为评估疾病严重程度及预后的指标。Objective To investigate the relationship between high-resolution CT(HRCT)phenotype and clinical features in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 95 patients with stable COPD admitted to the department of respiration in the hospital from February 2014 to March 2018 were enrolled in the study.All patients underwent HRCT,history collection and pulmonary function tests.The typing was conducted according to the results of HRCT examination.Differences in clinical indicators among patients with different types COPD were compared.Results There were 37 cases with type A,29 cases with type E and 29 cases with type M.There was no significant difference in the low-density attenuation area(LAA)score between type E and type M patients(P>0.05).The LAA scores of type A were significantly lower than those of the other two types(P<0.05).The dyspnea score,forced expiratory volume in 1s(FEV1)and the ratio of FEV1 to forced vital capacity(FEV1/FVC)of type A patients were significantly lower than those of type E and M patients(P<0.05).The expectoration score of type M patients was significantly higher than that of type A and E(P<0.05).Conclusion The HRCT phenotype is associated with clinical symptoms and pulmonary function indicators in patients with COPD,which can be used as an indicator to assess the severity and prognosis of the disease.

关 键 词：慢性阻塞性肺疾病 高分辨率CT 肺功能 

分 类 号：R322.35[医药卫生—人体解剖和组织胚胎学] R563[医药卫生—基础医学]