磁共振IVIM技术对T2DM肾病患者肾功能的评价价值  

Evaluated Value of Magnetic Resonance IVIM Technique in Renal Function of Patients with T2DM Nephropathy

作　　者：梁维 赵静 冯玲 何志婷 秦书敏 LIANG Wei;ZHAO Jing;FENG Ling(Department of Nephrology,The Ninth Hospital of Xi'an,Xi'an 710054,Shaanxi Province,China)

机构地区：[1]陕西省西安市第九医院肾脏内科,陕西西安710054 [2]陕西省汉中市中心医院医学影像诊断科,陕西汉中723000

出　　处：《中国CT和MRI杂志》2019年第12期81-83,共3页Chinese Journal of CT and MRI

基　　金：陕西省自然科学基金项目(2013JM4012)

摘　　要：目的观察磁共振体素内不相干运动成像(IVIM)技术对2型糖尿病(T2DM)肾病(DKD)患者肾功能的评价价值。方法选择2017年6月至2018年6月我院36例DKD患者为研究对象,纳入研究组;同时招募20例健康志愿者为对照组。均行MRI检查测得肾脏皮、髓质IVIM参数(单纯扩散系数D、灌注分数f),比较2组受试者肾小球滤过率(eGFR)差异,评价肾脏皮、髓质IVIM参数对DKD的诊断价值,分析肾脏皮、髓质IVIM参数与eGFR的相关性。结果研究组肾脏皮、髓质D、f值及eGFR均小于对照组(P<0.05)。皮质D、f值及髓质D、f值ROC曲线显示AUC分别为0.777、0.933、0.869、0.895(P<0.05),敏感性分别为0.806、0.833、0.833、0.722,特异性分别为0.806、0.950、0.800、0.900。肾脏皮、髓质D、f值与eGFR均呈显著正相关性(P<0.05)。结论IVIM可反映DKD肾脏灌注及弥散的变化,对DKD诊断及肾功能评价有一定价值。Objective To observe the evaluated value of magnetic resonance intravoxel incoherent motion imaging(IVIM)in the renal function of patients with type 2 diabetes mellitus(T2DM)nephropathy(DKD,diabetic kidney disease).Methods 36 patients with DKD in our hospital from June 2017 to June 2018 were selected as subjects and included in study group.Another 20 healthy volunteers recruited at the same time period were set as control group.MRI was performed,and the IVIM parameters of renal cortex and medulla(simple diffusion coefficient D,perfusion fraction f)were measured.The glomerular filtration rate(eGFR)was compared between the two groups.The diagnostic value of IVIM parameters of renal cortex and medulla on DKD was evaluated,and the correlation between IVIM parameters of renal cortex and medulla and eGFR was analyzed.Results The D and f values of renal cortex and medulla and eGFR in study group were smaller than those in control group(P<0.05).The AUC values of ROC cures of D and f values of cortex and D and f values of medulla were 0.777,0.933,0.869 and 0.895 respectively(P<0.05),and the sensitivities were 0.806,0.833,0.833 and 0.722 respectively,and the specificities were 0.806,0.950,0.800 and 0.900 respectively.The D and f values of renal cortex and medulla were significantly positively correlated with eGFR(P<0.05).Conclusion IVIM can reflect the changes of DKD renal perfusion and dispersion,and it has certain value for DKD diagnosis and renal function evaluation.

关 键 词：磁共振体素内不相干运动成像 2型糖尿病 糖尿病肾病 肾功能 

分 类 号：R587.1[医药卫生—内分泌] R445.2[医药卫生—内科学]