衰老病理机制与川产道地药材黄连的抗衰老效应研究进展  

Pathogenesis of Aging and Research Progress on Anti-aging Effects of Rhizoma Coptidis from Sichuan Daodi Herbs

作　　者：蒙雨丹 吴诗惠[2] 龚晓丽[2] 赵军宁[2] 李晓鲁 MENG Yudan;WU Shihui;GONG Xiaoli;ZHAO Junning;LI Xiaolu(Department of Plastic and Burn Surgery,the First Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Institute of Translational Pharmacology of Sichuan Academy of Chinese Medicine Sciences and Institute of Clinical Application,Sichuan Traditional Chinese Medicine Translational Medicine Center,Chengdu 610041,China)

机构地区：[1]西南医科大学附属第一医院整形烧伤外科,泸州646000 [2]四川省中医药科学院转化药理与临床应用研究所,四川省中医药转化医学中心,成都610041

出　　处：《世界中医药》2020年第2期208-213,共6页World Chinese Medicine

基　　金：四川省中医药管理局科技专项(2015Z006,2016C005);四川省科技厅科技支撑计划项目(2013SZ0115);四川省科技厅重点研发项目(2018SZ0056);2017年中医药公共卫生服务补助专项(财社[2017]66号);2018年中医药公共卫生服务补助专项(财社[2018]43号)

摘　　要：黄连作为川产道地药材在中医药历史上有重要地位。现代药理研究证明,黄连及其提取物在抗衰老、抗炎、抗肿瘤、调血脂、降血糖、神经保护等方面具有广泛的药理作用。衰老及其相关疾病在现代医学发展中具有重要意义,黄连及其提取物在抗衰老及衰老相关性疾病方面的效应及机制的研究进展,对发掘川产道地药材黄连的治疗新功效及新靶点,为其抗衰老新用途提供理论依据,为衰老及其相关疾病的临床治疗提供现代的科学依据及临床转化可能。Rhizoma Coptidis has an important position in the history of traditional Chinese medicine as a native medicinal material in Sichuan. Modern pharmacological research has further proved that the related biologically active components in Rhizoma Coptidis and its extracts have a wide range of pharmacological effects, which have a clear role in anti-aging, anti-inflammatory, anti-tumor, blood lipid regulation, hypoglycemic, neuro-protection. The effects and research progress of Rhizoma Coptidis and its extracts in anti-aging related aspects are highlighted by us. We look forward to discovering new therapeutic effects and new targets for the Chinese medicinal herbs Rhizoma Coptidis from the Sichuan. Secondly, it provides theoretical basis for new uses and further provides modern scientific basis for clinical applications.

关 键 词：黄连 生物碱 小柴碱 衰老 抗衰老 衰老相关性疾病 效应 机制 

分 类 号：R285.1[医药卫生—中药学]