咳喘宁胶囊联合布地奈德对老年咳嗽变异性哮喘病人炎症指标及疗效的影响  

Efficay of Kechuanning capsule combined with budesonide and its influence on the levels of inflammatory indicators in the elderly patients with cough variant asthma

作　　者：白晓瑞[1] 刘春娥 拓轩惠 BAI Xiao-rui;LIU Chun-e;TUO Xuan-hui(Department of Respiratory Medicine,Yulin First Hospital,Yulin 718000,China;De-partment of Respiratory and Critical Care Medicine,Affiliated Hospital of Yan′an University,Yan′an 716000,China)

机构地区：[1]榆林市第一医院呼吸内科,陕西省榆林市718000 [2]延安大学附属医院呼吸与危重症医学科,陕西省延安市716000

出　　处：《实用老年医学》2020年第1期66-69,共4页Practical Geriatrics

摘　　要：目的探究咳喘宁胶囊联合布地奈德对老年咳嗽变异性哮喘(CVA)病人炎症指标的影响及疗效。方法选择2015年11月至2018年6月我院收治的150例老年CVA病人作为研究对象,按照随机数字表法分为对照组及观察组,每组各75例。对照组予以布地奈德治疗,观察组在对照组基础上联合咳喘宁胶囊治疗。比较分析2组肺功能指标、炎症因子水平及临床疗效。结果治疗后,2组最大呼气流速峰值(PEF)、FVC、FEV1及哮喘控制测试(ACT)评分均明显上升(P<0.05),且观察组较对照组增加更显著(P<0.05);治疗后2组TNF-α、IL-6、IL-8、IgE水平均显著低于治疗前(P<0.05),且观察组较对照组更低(P<0.05)。观察组临床总有效率(92.54%)显著高于对照组(77.33%)(P<0.05)。2组治疗过程中均未出现相关不良反应。结论咳喘宁胶囊联合布地奈德联合治疗老年CVA可增强布地奈德在改善肺功能和降低炎症反应中的作用,临床疗效优于单用布地奈德。Objective To explore the efficay of Kechuanning capsule combined with budesonide and its influence on the levels of inflammatory indicators in the elderly patients with cough variant asthma( CVA). Methods A total of 150 elderly patients with CVA admitted to our hospital from November 2015 to June 2018 were selected and were divided into control group and observation group according to the random number table method,with 75 cases in each group. Both groups were treated with salbutamol treatment. The control group was treated with budesonide additionally, while the observation group was treated with Kechuanning capsule on the basis of the control group. The changes of pulmonary function,levels of inflammatory factors,clinical efficacy in the two groups were compared and analyzed. Results After treatment,the levels of peak expiratory flow( PEF),forced vital capacity( FVC),Forced expiratory volume in one second( FEV1) and the score of asthma control test( ACT) in the two groups were significantly increased than those before treatment( P<0. 05),especially in the observation group( P < 0. 05). The levels of immunoglobulin E( IgE),tumor neccosis factors-α( TNF-α),interleukin-6( IL-6) and IL-8 in two groups after treatment were significantly lower than those before treatment( P<0. 05),especially in the observation group( P < 0. 05). The total clinical effective rate of the observation group( 92. 54%) was significantly higher than that of the control group( 77. 33%,P <0. 05). There were no adverse reactions observed during the treatment in two groups. Conclusions Kechuanning capsule combined with budesonide can enhances the efficacy of budesonide in improving lung function and reducing inflammatory response in the elderly patients with CVA,which has better efficacy than budesonide only.

关 键 词：咳喘宁胶囊 布地奈德 咳嗽变异性哮喘 老年人 炎症指标 疗效 

分 类 号：R562.25[医药卫生—呼吸系统]