核纤层蛋白A翻译后修饰研究进展  

Progress on Post-Translational Modification of Lamin A

作　　者：廖自强 牛海涛[1] 王清水[1] 林尧[1] LIAO Zi-Qiang;NIU Hai-Tao;WANG Qing-Shui;LIN Yao(College of Life Sciences,Fujian Normal University,Fuzhou 350100,China)

机构地区：[1]福建师范大学生命科学学院

出　　处：《生物技术通讯》2019年第6期821-826,共6页Letters in Biotechnology

基　　金：福建省自然科学基金（2018J01723）

摘　　要：核纤层是核纤层蛋白在内核膜的核浆面形成的致密蛋白质网状结构,对维持细胞核形状、大小、结构稳定具有重要作用。研究表明,核纤层蛋白A的蛋白功能受泛素化、SUMO化、磷酸化、法尼基化等多种蛋白质翻译后修饰调控,核纤层蛋白A的翻译后修饰对其稳定性、亚细胞定位、DNA的结合与蛋白质的相互作用具有重要影响。The nuclear lamina is a dense protein network formed by lamins on the nucleoplasm surface of the inner membrane,and it plays an important role in maintaining the shape of the nucleus,the size of the nucleus,and the stability of the nuclear structure.Studies have shown that the protein function of lamin A is regulated by various post-translational modification,such as ubiquitination,SUMOylation,phosphorylation and farnesylation.The post-translational modification of lamin A has an important effect on its stability,subcellular localization,DNA binding and protein interaction.

关 键 词：核纤层蛋白A 翻译后修饰 细胞核 功能 

分 类 号：Q25[生物学—细胞生物学]