短期胰岛素强化治疗对新诊断2型糖尿病患者血糖控制临床研究  

Short-term Intensive Insulin Therapy for Newly Diagnosed Type 2 Diabetic Patients: Clinical Study of Blood Glucose Control

作　　者：陈冬云 陈宇浩 莫婉梨 吕键 胡德明 CHEN Dong-Yun;CHEN Yu-Hao;MO Wan-Li(Department of Protection,Dongguan Zhongtang Hospital,Dongguan 523220,Guangdong Province,China)

机构地区：[1]广东省东莞市中堂医院防保科,广东东莞523220 [2]广东省东莞市中堂医院内科,广东东莞523220 [3]广东省东莞市中堂医院中医康复科,广东东莞523220

出　　处：《罕少疾病杂志》2019年第6期41-43,共3页Journal of Rare and Uncommon Diseases

基　　金：东莞市科技项目，课题编号：201610515000488

摘　　要：目的评价分析短期胰岛素强化治疗对新诊断2型糖尿病(T2DM)患者血糖的影响效果。方法选择2016年3月-2017年10月期间东莞市中堂医院收治的新诊断2型糖尿病(T2DM)患者109例,并给予短期胰岛素强化治疗,观察比较治疗前后患者的胰岛β细胞功能指标及血糖的下降情况。结果患者治疗后FPG、2hPG、HbA1C均明显的低于治疗前(分别t=4.0276、8.9371、5.8409,P<0.05);FINS及HOMA-IR均显著地高于治疗前(分别t=4.2618、5.1357,P<0.05),而HOMA-β低于治疗前(分t=4.9715,P<0.05)。结论运用短期胰岛素强化治疗对新诊断2型糖尿病(T2DM)患者能够显著地长期良好控制血糖水平,改善胰岛β细胞功能,恢复胰岛素分泌,提高糖化血红蛋白达标率,值得临床大力推广应用。Objective To evaluate the effect of short-term insulin intensive treatment on blood glucose in patients with newly diagnosed type 2 diabetes(T2DM).Methods A total of 109 patients with newly diagnosed type 2 diabetes(T2DM)who were admitted to Dongguan Zhongtang Hospital from March 2016 to October 2017 were selected.Short-term insulin therapy was given to observe and compare the isletβ-cell function indicators and blood glucose before and after treatment.The decline situation.Results FPG,2hPG,and HbA1C were significantly lower than those before treatment(t=4.0276,8.9371,and 5.8409,respectively,P<0.05).Both FINS and HOMA-IR were significantly higher than before treatment(t=4.2618,5.1357,P<0.05,respectively),while HOMA-βwas lower than before treatment(t=4.9715,P<0.05).Conclusion The use of short-term insulin intensive treatment can significantly and long-termly control blood glucose levels,improveβ-cell function,restore insulin secretion,and improve the compliance rate of glycosylated hemoglobin in newly diagnosed patients with type 2 diabetes(T2DM).

关 键 词：新诊断2型糖尿病 短期胰岛素 强化治疗 血糖水平 

分 类 号：R459.1[医药卫生—治疗学] R587.1[医药卫生—临床医学]