孕产妇无乳链球菌感染现状和耐药性分析  

Analysis of maternal streptococcus infection and drug resistance

作　　者：吉维民[1] 许虹艳[2] Ji Weimin;Xu Hongyan(Department of Laboratory,People's Hosptal of Baoyin,Yangzhou,Jiangshu,225800,China;Department of Obstetrics and Gynecology,People's Hosptal of Baoyin,Yangzhou,Jiangshu,225800,China)

机构地区：[1]江苏省宝应县人民医院检验科,江苏扬州225800 [2]江苏省宝应县人民医院妇产科,江苏扬州225800

出　　处：《当代医学》2020年第5期95-97,共3页Contemporary Medicine

摘　　要：目的研究孕产妇无乳链球菌(B族链球,GBS)感染和耐药性,总结孕产妇无乳链球菌感染现况、趋势情况和耐药性。方法对本院妇产科2016年1月至2019年1月孕产妇阴道分泌物进行GBS培养和药敏试验,对实验数据进行归纳统计分析。结果 GBS对9种抗生菌耐药,对克林霉素耐药率60%,对红霉素耐药率约50%,其中D-试验检测诱导克林霉素耐药占35.6%,临床常用抗菌药物的耐药性呈上升趋势,共分离出GBS 75株,分离的无乳链球菌对万古霉素、青霉素、左氧氟沙星敏感性较好,对红霉素、阿奇霉素敏感性不佳,对克拉霉素、克林霉素耐药率较高,对头孢唑林,氯霉素耐药率较低,低于50%,临床可根据经验首选用药青霉素,万古霉素。耐克林霉素的GBS总体上相对较耐药。结论孕产妇本身GBS携带率有增高趋势,GBS对红霉素阿奇霉素耐药性增高,这可能与本院医生使用大环内酯类药物较频繁相关,检查孕产妇GBS对预防新生儿感染有重要作用。Objective To study the maternal Streptococcus agalactiae(Group B streptococcus, GBS) infection and drug resistance, and to summarize the status, trends and drug resistance of maternal S. agalactiae infections. Methods GBS culture and drug sensitivity tests were performed on vaginal secretions from pregnant women in the obstetrics and gynecology department of our hospital from January 2016 to January 2019, and the experimental data were summarized and statistically analyzed. Results GBS was resistant to 9 kinds of antibiotics, with a resistance rate of 60% to clindamycin and a resistance rate of about 50% to erythromycin. Among them, 35.6% was induced by D-test to detect resistance to clindamycin. Antimicrobial resistance is on the rise, and a total of 75 GBS strains have been isolated. The isolated Streptococcus agalactiae is more sensitive to vancomycin, penicillin, and levofloxacin, less sensitive to erythromycin and azithromycin, and clarithromycin The resistance rate of chloramphenicol and clindamycin is relatively high, and the resistance rate to chloramphenicol to cefazolin is low, which is less than 50%. Penicillin and vancomycin are the preferred drugs in clinical practice. Clindamycin-resistant GBS is generally relatively resistant. Conclusion The maternal GBS carrying rate is increasing, and GBS has increased resistance to erythromycin and azithromycin. This may be related to the frequent use of macrolides by doctors in our hospital. Examining maternal GBS is important for preventing neonatal infections.

关 键 词：无乳链球菌 B族链球菌 D-试验 耐药性分析 

分 类 号：R446.5[医药卫生—诊断学] R714.25[医药卫生—临床医学]